Antitumor and immunostimulating effects of Anoectochilus formosanus Hayata

C. C. Tseng, H. F. Shang, Leng-Fang Wang, B. Su, C. C. Hsu, H. Y. Kao, K. T. Cheng

Research output: Contribution to journalArticle

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Abstract

The water extract of Anoectochilus formosanus Hayata showed a potent tumor inhibitory activity in BALB/c mice after subcutaneous transplantation of CT-26 murine colon cancer cells. The tumor-inhibition ratios of mice pre-administered with A. formosanus for 2 days before tumor transplantation, and treated further for 12 consecutive days, were 55.4% and 58.9% at the oral dose of 50 and 10 mg/mouse per day, respectively. Even for the tumor-bearing mice, after oral administration of the water extract of A. formosanus for 12 consecutive days, the tumor inhibition ratios were still 23.8% and 40.5% at doses of 50 and 10 mg/mouse, respectively. Because the low-concentration water extract of A. formosanus does not show direct cytotoxicity in CT-26 tumor cells, we observed further that oral administration of the water extract of A. formosanus may activate murine immune responses, such as stimulating the proliferation of lymphoid tissues and activating the phagocytosis of peritoneal macrophages against Staphylococcus aureus. This study suggests that the antitumor activity of A. formosanus may be associated with its potent immunostimulating effect. It is worth further analyzing the immunomodulating component purified from A. formosanus, and evaluating its potential value for the treatment of human cancers.

Original languageEnglish
Pages (from-to)366-370
Number of pages5
JournalPhytomedicine
Volume13
Issue number5
DOIs
Publication statusPublished - May 9 2006

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Tumors
mice
neoplasms
Neoplasms
Water
extracts
Bearings (structural)
oral administration
Oral Administration
Cells
Transplantation
water
Macrophages
Cytotoxicity
Peritoneal Macrophages
Lymphoid Tissue
dosage
Anoectochilus formosanus
phagocytosis
colorectal neoplasms

Keywords

  • Anoectochilus formosanus
  • In vivo antitumoral and immunostimulating activity

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Antitumor and immunostimulating effects of Anoectochilus formosanus Hayata. / Tseng, C. C.; Shang, H. F.; Wang, Leng-Fang; Su, B.; Hsu, C. C.; Kao, H. Y.; Cheng, K. T.

In: Phytomedicine, Vol. 13, No. 5, 09.05.2006, p. 366-370.

Research output: Contribution to journalArticle

Tseng, C. C. ; Shang, H. F. ; Wang, Leng-Fang ; Su, B. ; Hsu, C. C. ; Kao, H. Y. ; Cheng, K. T. / Antitumor and immunostimulating effects of Anoectochilus formosanus Hayata. In: Phytomedicine. 2006 ; Vol. 13, No. 5. pp. 366-370.
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