Antitumor agents. Part 3: Synthesis and cytotoxicity of new trans-stilbene benzenesulfonamide derivatives

Li Ming Yang, Shwu Jiuan Lin, Fen Lin Hsu, Tsang Hsiung Yang

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21 Citations (Scopus)


A new series of trans-stilbene benzenesulfonamide derivatives were designed and synthesized as potential antitumor agents. These new compounds were evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. Compounds 9-13 were cytotoxic against several cell lines. Notably, two compounds, 9 and 12, demonstrated selective cytotoxic activity against BT-549 breast cancer (GI50=0.205 μM) and HT-29 colon cancer (GI50=0.554 μM), respectively.

Original languageEnglish
Pages (from-to)1013-1015
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number7
Publication statusPublished - Apr 8 2002


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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