Antitumor agents. Part 3: Synthesis and cytotoxicity of new trans-stilbene benzenesulfonamide derivatives

Li Ming Yang, Shwu Jiuan Lin, Fen Lin Hsu, Tsang Hsiung Yang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A new series of trans-stilbene benzenesulfonamide derivatives were designed and synthesized as potential antitumor agents. These new compounds were evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. Compounds 9-13 were cytotoxic against several cell lines. Notably, two compounds, 9 and 12, demonstrated selective cytotoxic activity against BT-549 breast cancer (GI50=0.205 μM) and HT-29 colon cancer (GI50=0.554 μM), respectively.

Original languageEnglish
Pages (from-to)1013-1015
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number7
DOIs
Publication statusPublished - Apr 8 2002

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Stilbenes
National Cancer Institute (U.S.)
Cytotoxicity
Tumor Cell Line
Antineoplastic Agents
Colonic Neoplasms
Cells
Breast Neoplasms
Derivatives
Cell Line
Tumors
In Vitro Techniques
benzenesulfonamide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Antitumor agents. Part 3 : Synthesis and cytotoxicity of new trans-stilbene benzenesulfonamide derivatives. / Yang, Li Ming; Lin, Shwu Jiuan; Hsu, Fen Lin; Yang, Tsang Hsiung.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 12, No. 7, 08.04.2002, p. 1013-1015.

Research output: Contribution to journalArticle

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