Derivatives of the quinazolinocarboline alkaloid rutaecarpine, including 10-bromorutaecarpine (1), were synthesized and evaluated for cytotoxicity against several human tumor cell lines. The more potent derivative found in this study was compound 1, which exhibited significant activity against SF- 295 and ovarian cancer cell lines.
|Number of pages||7|
|Journal||Chinese Pharmaceutical Journal|
|Publication status||Published - Jun 1999|
- Evodia rutaecarpa
- Quinazolinocarboline alkaloid
ASJC Scopus subject areas
- Pharmaceutical Science