Antitumor activity of four macrocyclic ellagitannins from Cuphea hyssopifolia

Ching Chiung Wang; Lih Geeng Chen; Ling-Ling Yang

doi:10.1016/S0304-3835(99)00071-3

Antitumor activity of four macrocyclic ellagitannins from Cuphea hyssopifolia

Ching Chiung Wang, Lih Geeng Chen, Ling-Ling Yang

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

We evaluated the antitumor activities of four macrocyclic hydrolyzable tannin dimers, cuphiin D₁, cuphiin D₂, oenothein B and woodfordin C isolated from Cuphea hyssopifolia (Lythraceae). All significantly inhibited the growth of the human carcinoma cell lines KB, HeLa, DU-145, Hep 3B, and the leukemia cell line HL-60, and showed less cytotoxicity than adriamycin against a normal cell line (WISH). All four compounds inhibited the viability of S-180 tumor cells in an in vitro assay and an in vivo S-180 tumor-bearing ICR mice model. Oenothein B demonstrated the greatest cytotoxicity (IC₅₀=11.4 μg/ml) against S-180 tumor cells in culture, while cuphiin D₁ resulted in the greatest increase in survival on S-180 tumor-bearing mice (%ILS=84.1%). Our findings suggest that the antitumor effects of these compounds are not only related to their cytotoxicity on carcinoma cell lines, but also depended on a host-mediated mechanism; they may therefore have potential for antitumor applications. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	195-200
Number of pages	6
Journal	Cancer Letters
Volume	140
Issue number	1-2
DOIs	https://doi.org/10.1016/S0304-3835(99)00071-3
Publication status	Published - Jun 1 1999

Keywords

Antitumor activity in vivo and in vitro
Cuphiin D
Cuphiin D
Oenothein B
Woodfordin C

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(99)00071-3

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title = "Antitumor activity of four macrocyclic ellagitannins from Cuphea hyssopifolia",

abstract = "We evaluated the antitumor activities of four macrocyclic hydrolyzable tannin dimers, cuphiin D1, cuphiin D2, oenothein B and woodfordin C isolated from Cuphea hyssopifolia (Lythraceae). All significantly inhibited the growth of the human carcinoma cell lines KB, HeLa, DU-145, Hep 3B, and the leukemia cell line HL-60, and showed less cytotoxicity than adriamycin against a normal cell line (WISH). All four compounds inhibited the viability of S-180 tumor cells in an in vitro assay and an in vivo S-180 tumor-bearing ICR mice model. Oenothein B demonstrated the greatest cytotoxicity (IC50=11.4 μg/ml) against S-180 tumor cells in culture, while cuphiin D1 resulted in the greatest increase in survival on S-180 tumor-bearing mice (%ILS=84.1%). Our findings suggest that the antitumor effects of these compounds are not only related to their cytotoxicity on carcinoma cell lines, but also depended on a host-mediated mechanism; they may therefore have potential for antitumor applications. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

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AB - We evaluated the antitumor activities of four macrocyclic hydrolyzable tannin dimers, cuphiin D1, cuphiin D2, oenothein B and woodfordin C isolated from Cuphea hyssopifolia (Lythraceae). All significantly inhibited the growth of the human carcinoma cell lines KB, HeLa, DU-145, Hep 3B, and the leukemia cell line HL-60, and showed less cytotoxicity than adriamycin against a normal cell line (WISH). All four compounds inhibited the viability of S-180 tumor cells in an in vitro assay and an in vivo S-180 tumor-bearing ICR mice model. Oenothein B demonstrated the greatest cytotoxicity (IC50=11.4 μg/ml) against S-180 tumor cells in culture, while cuphiin D1 resulted in the greatest increase in survival on S-180 tumor-bearing mice (%ILS=84.1%). Our findings suggest that the antitumor effects of these compounds are not only related to their cytotoxicity on carcinoma cell lines, but also depended on a host-mediated mechanism; they may therefore have potential for antitumor applications. Copyright (C) 1999 Elsevier Science Ireland Ltd.

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Antitumor activity of four macrocyclic ellagitannins from Cuphea hyssopifolia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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