Antitumor activity of four macrocyclic ellagitannins from Cuphea hyssopifolia

Ching Chiung Wang, Lih Geeng Chen, Ling Ling Yang

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

We evaluated the antitumor activities of four macrocyclic hydrolyzable tannin dimers, cuphiin D1, cuphiin D2, oenothein B and woodfordin C isolated from Cuphea hyssopifolia (Lythraceae). All significantly inhibited the growth of the human carcinoma cell lines KB, HeLa, DU-145, Hep 3B, and the leukemia cell line HL-60, and showed less cytotoxicity than adriamycin against a normal cell line (WISH). All four compounds inhibited the viability of S-180 tumor cells in an in vitro assay and an in vivo S-180 tumor-bearing ICR mice model. Oenothein B demonstrated the greatest cytotoxicity (IC50=11.4 μg/ml) against S-180 tumor cells in culture, while cuphiin D1 resulted in the greatest increase in survival on S-180 tumor-bearing mice (%ILS=84.1%). Our findings suggest that the antitumor effects of these compounds are not only related to their cytotoxicity on carcinoma cell lines, but also depended on a host-mediated mechanism; they may therefore have potential for antitumor applications. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalCancer Letters
Volume140
Issue number1-2
DOIs
Publication statusPublished - Jun 1 1999
Externally publishedYes

Fingerprint

Cuphea
Hydrolyzable Tannins
Cell Line
Lythraceae
Neoplasms
Carcinoma
Inbred ICR Mouse
Doxorubicin
Inhibitory Concentration 50
Leukemia
Cell Culture Techniques
Survival
Growth

Keywords

  • Antitumor activity in vivo and in vitro
  • Cuphiin D
  • Cuphiin D
  • Oenothein B
  • Woodfordin C

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Antitumor activity of four macrocyclic ellagitannins from Cuphea hyssopifolia. / Wang, Ching Chiung; Chen, Lih Geeng; Yang, Ling Ling.

In: Cancer Letters, Vol. 140, No. 1-2, 01.06.1999, p. 195-200.

Research output: Contribution to journalArticle

Wang, Ching Chiung ; Chen, Lih Geeng ; Yang, Ling Ling. / Antitumor activity of four macrocyclic ellagitannins from Cuphea hyssopifolia. In: Cancer Letters. 1999 ; Vol. 140, No. 1-2. pp. 195-200.
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