Antiproliferative effects of goniothalamin on Ca9-22 oral cancer cells through apoptosis, DNA damage and ROS induction

Ching Yu Yen, Chien Chih Chiu, Rou Wen Haung, Chi Chen Yeh, Kuang Jing Huang, Kuo Feng Chang, You Cheng Hseu, Fang Rong Chang, Hsueh Wei Chang, Yang Chang Wu

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Goniothalamin (GTN), a plant bioactive styryl-lactone, is a natural product with potent anti-tumorigenesis effects for several types of cancer. Nonetheless, the anticancer effect of GTN has not been examined in oral cancer. The present study was designed to evaluate its potential anticancer effects in an oral squamous cell carcinoma (OSCC) model and to determine the possible mechanisms with respect to apoptosis, DNA damage, reactive oxygen species (ROS) induction, and mitochondrial membrane potential. Our data demonstrated that cell proliferation was significantly inhibited by GTN in Ca9-22 OSCC cancer cells in concentration- and time-dependent manners (p2(3) (3,3'-diethyloxacarbocyanine iodide) intensity of GTN-treated Ca9-22 cancer cells was significantly decreased in concentration- and time-dependent relationships (p

Original languageEnglish
Pages (from-to)253-258
Number of pages6
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume747
Issue number2
DOIs
Publication statusPublished - Sep 18 2012

Keywords

  • γH2AX
  • Apoptosis
  • Goniothalamin
  • Mitochondrial membrane potential
  • Oral cancer
  • ROS

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Genetics

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