Antioxidative status of patients with alcoholic liver disease in southeastern Taiwan

Ya Ling Chen, Li Ju Chen, Ming Jong Bair, Mei Lan Yao, Hsiang Chi Peng, Sien Sing Yang, Suh Ching Yang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

AIM: To investigate the antioxidative status of patients with alcoholic liver disease (ALD) in southeastern Taiwan. METHODS: Our study comprised 27 patients with ALD recruited from Taitung Mackay Memorial Hospital, located in southeastern Taiwan. Patients with ALD included 12 non-aborigines (12 men) and 15 aborigines (11 men and 4 women). According to the severity of ALD, patients with ALD included 10 with hepatitis (9 men and 1 woman) and 17 with cirrhosis (14 men and 3 women). Twenty-two age- and gender-matched healthy adults served as the control group in this study. Venous blood (10 mL) of each subject was drawn into EDTA-containing tubes after 8 h overnight fasting. RESULTS: Compared to the control group, patients with ALD showed significantly lower erythrocytic catalase (11.1 ± 0.7 U/mg Hb vs 8.0 ± 0.7 U/mg Hb, P <0.05) and superoxide dismutase (9.5 ± 1.6 U/mg Hb vs 3.0 ± 0.2 U/mg Hb, P <0.05) activities. Furthermore, the erythrocytic reduced glutathione/oxidized glutathione ratio was significantly lower in ALD patients than that in the control group (38.1 ± 5.4 vs 15.7 ± 1.9, P <0.05). The results revealed that patients with ALD experienced more oxidative stress than those in the control group. The non-aboriginal, but not the aboriginal, ALD group had higher erythrocytic glutathione peroxidase (GPX) activity than that in the control group (46.1 ± 7.8 U/g Hb vs 27.9 ± 2.2 U/g Hb, P <0.05). Hepatitis, but not cirrhosis, ALD patients had higher erythrocytic GPX activity than that in the control group (44.3 ± 8.6 U/g Hb vs 27.9 ± 2.2 U/g Hb, P <0.05). CONCLUSION: Our results indicate that both ethnicity and the severity of ALD may cause different erythrocytic antioxidative enzyme activities especially GPX activity.

Original languageEnglish
Pages (from-to)1063-1070
Number of pages8
JournalWorld Journal of Gastroenterology
Volume17
Issue number8
DOIs
Publication statusPublished - Feb 28 2011

Fingerprint

Alcoholic Liver Diseases
Taiwan
Control Groups
Glutathione Peroxidase
Hepatitis
Fibrosis
Glutathione Disulfide
Edetic Acid
Catalase
Superoxide Dismutase
Glutathione
Fasting
Oxidative Stress

Keywords

  • Aborigines
  • Alcoholic liver disease
  • Antioxidative status
  • Cirrhosis
  • Hepatitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Antioxidative status of patients with alcoholic liver disease in southeastern Taiwan. / Chen, Ya Ling; Chen, Li Ju; Bair, Ming Jong; Yao, Mei Lan; Peng, Hsiang Chi; Yang, Sien Sing; Yang, Suh Ching.

In: World Journal of Gastroenterology, Vol. 17, No. 8, 28.02.2011, p. 1063-1070.

Research output: Contribution to journalArticle

Chen, Ya Ling ; Chen, Li Ju ; Bair, Ming Jong ; Yao, Mei Lan ; Peng, Hsiang Chi ; Yang, Sien Sing ; Yang, Suh Ching. / Antioxidative status of patients with alcoholic liver disease in southeastern Taiwan. In: World Journal of Gastroenterology. 2011 ; Vol. 17, No. 8. pp. 1063-1070.
@article{6ece476a801d40c786d1511cc29ff423,
title = "Antioxidative status of patients with alcoholic liver disease in southeastern Taiwan",
abstract = "AIM: To investigate the antioxidative status of patients with alcoholic liver disease (ALD) in southeastern Taiwan. METHODS: Our study comprised 27 patients with ALD recruited from Taitung Mackay Memorial Hospital, located in southeastern Taiwan. Patients with ALD included 12 non-aborigines (12 men) and 15 aborigines (11 men and 4 women). According to the severity of ALD, patients with ALD included 10 with hepatitis (9 men and 1 woman) and 17 with cirrhosis (14 men and 3 women). Twenty-two age- and gender-matched healthy adults served as the control group in this study. Venous blood (10 mL) of each subject was drawn into EDTA-containing tubes after 8 h overnight fasting. RESULTS: Compared to the control group, patients with ALD showed significantly lower erythrocytic catalase (11.1 ± 0.7 U/mg Hb vs 8.0 ± 0.7 U/mg Hb, P <0.05) and superoxide dismutase (9.5 ± 1.6 U/mg Hb vs 3.0 ± 0.2 U/mg Hb, P <0.05) activities. Furthermore, the erythrocytic reduced glutathione/oxidized glutathione ratio was significantly lower in ALD patients than that in the control group (38.1 ± 5.4 vs 15.7 ± 1.9, P <0.05). The results revealed that patients with ALD experienced more oxidative stress than those in the control group. The non-aboriginal, but not the aboriginal, ALD group had higher erythrocytic glutathione peroxidase (GPX) activity than that in the control group (46.1 ± 7.8 U/g Hb vs 27.9 ± 2.2 U/g Hb, P <0.05). Hepatitis, but not cirrhosis, ALD patients had higher erythrocytic GPX activity than that in the control group (44.3 ± 8.6 U/g Hb vs 27.9 ± 2.2 U/g Hb, P <0.05). CONCLUSION: Our results indicate that both ethnicity and the severity of ALD may cause different erythrocytic antioxidative enzyme activities especially GPX activity.",
keywords = "Aborigines, Alcoholic liver disease, Antioxidative status, Cirrhosis, Hepatitis",
author = "Chen, {Ya Ling} and Chen, {Li Ju} and Bair, {Ming Jong} and Yao, {Mei Lan} and Peng, {Hsiang Chi} and Yang, {Sien Sing} and Yang, {Suh Ching}",
year = "2011",
month = "2",
day = "28",
doi = "10.3748/wjg.v17.i8.1063",
language = "English",
volume = "17",
pages = "1063--1070",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "8",

}

TY - JOUR

T1 - Antioxidative status of patients with alcoholic liver disease in southeastern Taiwan

AU - Chen, Ya Ling

AU - Chen, Li Ju

AU - Bair, Ming Jong

AU - Yao, Mei Lan

AU - Peng, Hsiang Chi

AU - Yang, Sien Sing

AU - Yang, Suh Ching

PY - 2011/2/28

Y1 - 2011/2/28

N2 - AIM: To investigate the antioxidative status of patients with alcoholic liver disease (ALD) in southeastern Taiwan. METHODS: Our study comprised 27 patients with ALD recruited from Taitung Mackay Memorial Hospital, located in southeastern Taiwan. Patients with ALD included 12 non-aborigines (12 men) and 15 aborigines (11 men and 4 women). According to the severity of ALD, patients with ALD included 10 with hepatitis (9 men and 1 woman) and 17 with cirrhosis (14 men and 3 women). Twenty-two age- and gender-matched healthy adults served as the control group in this study. Venous blood (10 mL) of each subject was drawn into EDTA-containing tubes after 8 h overnight fasting. RESULTS: Compared to the control group, patients with ALD showed significantly lower erythrocytic catalase (11.1 ± 0.7 U/mg Hb vs 8.0 ± 0.7 U/mg Hb, P <0.05) and superoxide dismutase (9.5 ± 1.6 U/mg Hb vs 3.0 ± 0.2 U/mg Hb, P <0.05) activities. Furthermore, the erythrocytic reduced glutathione/oxidized glutathione ratio was significantly lower in ALD patients than that in the control group (38.1 ± 5.4 vs 15.7 ± 1.9, P <0.05). The results revealed that patients with ALD experienced more oxidative stress than those in the control group. The non-aboriginal, but not the aboriginal, ALD group had higher erythrocytic glutathione peroxidase (GPX) activity than that in the control group (46.1 ± 7.8 U/g Hb vs 27.9 ± 2.2 U/g Hb, P <0.05). Hepatitis, but not cirrhosis, ALD patients had higher erythrocytic GPX activity than that in the control group (44.3 ± 8.6 U/g Hb vs 27.9 ± 2.2 U/g Hb, P <0.05). CONCLUSION: Our results indicate that both ethnicity and the severity of ALD may cause different erythrocytic antioxidative enzyme activities especially GPX activity.

AB - AIM: To investigate the antioxidative status of patients with alcoholic liver disease (ALD) in southeastern Taiwan. METHODS: Our study comprised 27 patients with ALD recruited from Taitung Mackay Memorial Hospital, located in southeastern Taiwan. Patients with ALD included 12 non-aborigines (12 men) and 15 aborigines (11 men and 4 women). According to the severity of ALD, patients with ALD included 10 with hepatitis (9 men and 1 woman) and 17 with cirrhosis (14 men and 3 women). Twenty-two age- and gender-matched healthy adults served as the control group in this study. Venous blood (10 mL) of each subject was drawn into EDTA-containing tubes after 8 h overnight fasting. RESULTS: Compared to the control group, patients with ALD showed significantly lower erythrocytic catalase (11.1 ± 0.7 U/mg Hb vs 8.0 ± 0.7 U/mg Hb, P <0.05) and superoxide dismutase (9.5 ± 1.6 U/mg Hb vs 3.0 ± 0.2 U/mg Hb, P <0.05) activities. Furthermore, the erythrocytic reduced glutathione/oxidized glutathione ratio was significantly lower in ALD patients than that in the control group (38.1 ± 5.4 vs 15.7 ± 1.9, P <0.05). The results revealed that patients with ALD experienced more oxidative stress than those in the control group. The non-aboriginal, but not the aboriginal, ALD group had higher erythrocytic glutathione peroxidase (GPX) activity than that in the control group (46.1 ± 7.8 U/g Hb vs 27.9 ± 2.2 U/g Hb, P <0.05). Hepatitis, but not cirrhosis, ALD patients had higher erythrocytic GPX activity than that in the control group (44.3 ± 8.6 U/g Hb vs 27.9 ± 2.2 U/g Hb, P <0.05). CONCLUSION: Our results indicate that both ethnicity and the severity of ALD may cause different erythrocytic antioxidative enzyme activities especially GPX activity.

KW - Aborigines

KW - Alcoholic liver disease

KW - Antioxidative status

KW - Cirrhosis

KW - Hepatitis

UR - http://www.scopus.com/inward/record.url?scp=79955937900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955937900&partnerID=8YFLogxK

U2 - 10.3748/wjg.v17.i8.1063

DO - 10.3748/wjg.v17.i8.1063

M3 - Article

VL - 17

SP - 1063

EP - 1070

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 8

ER -