Antioxidative natural product protect against econazole-induced liver injuries

Chi Feng Liu, Chia Hsien Lin, Chun Ching Lin, Yun Ho Lin, Chin Fa Chen, Chao Kuang Lin, Song-Chow Lin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The study objective of this research is in order to investigate the hepatoprotective and therapeutic effects of propolis ethanol extract (PEE) on acute econazole-induced liver injury. Positive control of various concentrations of PEE on liver function and the dose-response relationship of liver injury induced by various doses of econazole were firstly observed from biochemical assay of serum level of aspartate transaminase (SGOT) and serum alanine transaminase (SGPT) and histopathological microscopic examination. The hepatoprotective effects of various concentration of PEE on liver damage induced by hepatotoxic dose (300mg/kg) of econazole were observed by the obvious decrement of SGOT and SGPT level and further confirmed by hepatohistological microscopic examination. The inhibitory effects of PEE on FeCl2-induced (in vitro) or econazole-induced (in vivo) lipid peroxidation were investigated from the measurement of the formed malonic dialdehyde (MDA) level in the rat liver homogenate. The IC50 (μM) of various concentrations of PEE in the superoxide scavenging activity in econazole (300mg/kg)-damaged rat liver homogenate were assessed by cytochrome c reduction method and compared with that of (+)-alpha-tocopherol. It could be postulated that the hepatoprotective effect of PEE may be, at least in part, due to their inhibitory ability on membrane lipid peroxidation and free radical formation or due to their free radical scavenging ability.

Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalToxicology
Volume196
Issue number1-2
DOIs
Publication statusPublished - Mar 1 2004

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Econazole
Propolis
Biological Products
Liver
Ethanol
Wounds and Injuries
Aspartate Aminotransferases
Alanine Transaminase
Liver Extracts
Scavenging
Lipid Peroxidation
Free Radicals
Rats
Microscopic examination
alpha-Tocopherol
Therapeutic Uses
Membrane Lipids
Cytochromes c
Serum
Superoxides

Keywords

  • Cytochrome c
  • Econazole
  • Malonic dialdehyde
  • Propolis ethanol extract

ASJC Scopus subject areas

  • Toxicology

Cite this

Liu, C. F., Lin, C. H., Lin, C. C., Lin, Y. H., Chen, C. F., Lin, C. K., & Lin, S-C. (2004). Antioxidative natural product protect against econazole-induced liver injuries. Toxicology, 196(1-2), 87-93. https://doi.org/10.1016/j.tox.2003.11.007

Antioxidative natural product protect against econazole-induced liver injuries. / Liu, Chi Feng; Lin, Chia Hsien; Lin, Chun Ching; Lin, Yun Ho; Chen, Chin Fa; Lin, Chao Kuang; Lin, Song-Chow.

In: Toxicology, Vol. 196, No. 1-2, 01.03.2004, p. 87-93.

Research output: Contribution to journalArticle

Liu, CF, Lin, CH, Lin, CC, Lin, YH, Chen, CF, Lin, CK & Lin, S-C 2004, 'Antioxidative natural product protect against econazole-induced liver injuries', Toxicology, vol. 196, no. 1-2, pp. 87-93. https://doi.org/10.1016/j.tox.2003.11.007
Liu, Chi Feng ; Lin, Chia Hsien ; Lin, Chun Ching ; Lin, Yun Ho ; Chen, Chin Fa ; Lin, Chao Kuang ; Lin, Song-Chow. / Antioxidative natural product protect against econazole-induced liver injuries. In: Toxicology. 2004 ; Vol. 196, No. 1-2. pp. 87-93.
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