Antioxidant status in patients with Parkinson's disease

Rey Yue Yuan, Mei Yiao Wu, Xue-Ping Hu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In order to determine the antioxidative status in Parkinson's disease (PD) patients, concentrations of antioxidant vitamins and the activity of antioxidant enzymes were measured in 26 PD patients (13 ♂, 13 ♀, mean age of 70 old) as well as the age- and sex-matched control subjects. All subjects were resided in Taipei area. There was no significant difference in plasma concentrations of vitamins A, C, and E between the 2 groups. However, the antioxidant activity of superoxide dismutase (SOD), glutathione peroxidase (GSHPx), and the total antioxidant status (TAS) were significant lower in the PD patient group than those in the control group (P <0.001). Patients in advanced stage had significantly lower SOD activity than did early -stage patients (P <0.05). There was no correlation between the severity or duration of Parkinson's disease and concentrations of antioxidant vitamins and other parameters. Only SOD activity was negatively correlated with the severity of PD (r = -0.59, P <0.05), but it was not related with age or duration of the disease. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)647-652
Number of pages6
JournalNutrition Research
Volume20
Issue number5
DOIs
Publication statusPublished - May 2000

Keywords

  • Antioxidant vitamins
  • Glutathione peroxidase
  • Parkinson's disease
  • Superoxide dismutase

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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