Antioxidant and amine oxidase inhibitory activities of hydroxyurea

Yuh Hwa Liu, Wen Chun Wu, Yeh Lin Lu, Ying Jang Lai, Wen Chi Hou

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Hydroxyurea (HU, NH2CONHOH), or hydroxycar- bamide, is a hydroxamic acid derivative used as a drug for anti-neoplasm and sickle-cell disease. In this study, HU was found to have antioxidant activities against 2,2- diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals and dose-dependent inhibitory activities against monoamine oxidase (MAO)-A, MAO-B, and semicar- bazide-sensitive amine oxidase (SSAO) as compared to controls of clorgyline, deprenyl, and semicarbazide respectively. HU showed mixed-type, competitive-type, and competitive-type inhibition, respectively, with respect to substrates of MAO-A, MAO-B, and SSAO with apparent inhibition constants (Ki) of 19.46, 5.38, and 1.84 μM.

Original languageEnglish
Pages (from-to)1256-1260
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume74
Issue number6
DOIs
Publication statusPublished - 2010

Keywords

  • Antioxidant activity
  • Hydroxyurea (HU)
  • Monoamine oxidase (MAO)
  • Semicarbaitive amine oxidase (SSAO)

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry
  • Medicine(all)

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