Antioxidant and amine oxidase inhibitory activities of hydroxyurea

Yuh Hwa Liu, Wen Chun Wu, Yeh Lin Lu, Ying Jang Lai, Wen Chi Hou

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Hydroxyurea (HU, NH2CONHOH), or hydroxycar- bamide, is a hydroxamic acid derivative used as a drug for anti-neoplasm and sickle-cell disease. In this study, HU was found to have antioxidant activities against 2,2- diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals and dose-dependent inhibitory activities against monoamine oxidase (MAO)-A, MAO-B, and semicar- bazide-sensitive amine oxidase (SSAO) as compared to controls of clorgyline, deprenyl, and semicarbazide respectively. HU showed mixed-type, competitive-type, and competitive-type inhibition, respectively, with respect to substrates of MAO-A, MAO-B, and SSAO with apparent inhibition constants (Ki) of 19.46, 5.38, and 1.84 μM.

Original languageEnglish
Pages (from-to)1256-1260
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume74
Issue number6
DOIs
Publication statusPublished - 2010

Fingerprint

Hydroxyurea
Monoamine Oxidase
Amines
Oxidoreductases
Antioxidants
Clorgyline
Hydroxamic Acids
Amine Oxidase (Copper-Containing)
Selegiline
Sickle Cell Anemia
Hydroxyl Radical
Derivatives
Substrates
Pharmaceutical Preparations
Neoplasms

Keywords

  • Antioxidant activity
  • Hydroxyurea (HU)
  • Monoamine oxidase (MAO)
  • Semicarbaitive amine oxidase (SSAO)

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry
  • Medicine(all)

Cite this

Antioxidant and amine oxidase inhibitory activities of hydroxyurea. / Liu, Yuh Hwa; Wu, Wen Chun; Lu, Yeh Lin; Lai, Ying Jang; Hou, Wen Chi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 74, No. 6, 2010, p. 1256-1260.

Research output: Contribution to journalArticle

Liu, Yuh Hwa ; Wu, Wen Chun ; Lu, Yeh Lin ; Lai, Ying Jang ; Hou, Wen Chi. / Antioxidant and amine oxidase inhibitory activities of hydroxyurea. In: Bioscience, Biotechnology and Biochemistry. 2010 ; Vol. 74, No. 6. pp. 1256-1260.
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