Antioxidant activity of Ganoderma lucidum in acute ethanol-induced heart toxicity

Kar Lok Wong, Hung Hsing Chao, Paul Chan, Li Ping Chang, Chi Feng Liu

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The hot water extract of the mushroom Ganoderma lucidum was shown to have antioxidative effect against heart toxicity. Investigations into the mechanisms of action, level of lipid peroxidation level in vivo, and superoxide scavenging activity were also conducted. The mice were divided into six groups with ten animals in each group. Ganoderma lucidum, at doses of 10, 25 and 50 mg/kg (p.o.) was administered. Superoxide anions were assayed by UV spectrophotometer using the cytochrome C reduction method. The results of this study showed that Ganoderma lucidum exhibited a dose-dependent antioxidative effect on lipid peroxidation and superoxide scavenging activity in mouse heart homogenate. Additionally, this result indicated that heart damage induced by ethanol shows a higher malonic dialdehyde level compared with heart homogenate treated with Ganoderma lucidum. It is concluded that the antioxidative activity may therefore contribute to the cardioprotective effect of Ganoderma lucidum, and may therefore protect the heart from superoxide induced damage.

Original languageEnglish
Pages (from-to)1024-1026
Number of pages3
JournalPhytotherapy Research
Volume18
Issue number12
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Antioxidant activity
  • Ganoderma lucidum
  • Heart toxicity
  • Lipid peroxidation
  • Malonic dialdehyde

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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