Antioxidant activity and constituents of extracts from the root of Garcinia multiflora

Jyh Horng Wu, Yu Tang Tung, Chiou Fung Chyu, Shih Chang Chien, Sheng Yang Wang, Shang Tzen Chang, Yueh Hsiung Kuo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The methanolic extract of the root of Garcinia multiflora and its derived soluble fractions, namely those soluble in ethyl acetate (EtOAc), n-butanol, and water, were screened for their antioxidant activities. Among them, the EtOAc-soluble fraction exhibited the highest scavenging activity against the 1,1-dipheny1,2-picrylhydrazyl radical, the highest superoxide radical scavenging activity, and the strongest reducing power. In addition, according to the bioactivity-guided isolation, 26 specific phytocompounds, including 3 aromatics, 3 benzophenones, 3 flavonoids, 3 isocoumarins, 1 phloroglucinol, 6 steroids, and 7 xanthones, were isolated from the EtOAc-soluble fraction and identified. Of these, 2,4,3′,4′-tetrahydroxy-6-methoxybenzophenone and 1,3,6,7-tetrahydroxyxanthone were found to be the major bioactive constituents, present in the crude extract in concentrations of 3.9 and 15.6 mg/g, respectively. These two compounds had similar antioxidant activities to (+)-catechin, a well-known antioxidant.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalJournal of Wood Science
Volume54
Issue number5
DOIs
Publication statusPublished - Oct 2008
Externally publishedYes

Fingerprint

Garcinia
Antioxidants
Scavenging
Phloroglucinol
Xanthones
Flavonoids
1-Butanol
Catechin
Bioactivity
Complex Mixtures
Butenes
Superoxides
Steroids
Water

Keywords

  • Antioxidant
  • Bioactivity-guided isolation
  • Garcinia multiflora
  • Phytocompound
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biomaterials

Cite this

Antioxidant activity and constituents of extracts from the root of Garcinia multiflora. / Wu, Jyh Horng; Tung, Yu Tang; Chyu, Chiou Fung; Chien, Shih Chang; Wang, Sheng Yang; Chang, Shang Tzen; Kuo, Yueh Hsiung.

In: Journal of Wood Science, Vol. 54, No. 5, 10.2008, p. 383-389.

Research output: Contribution to journalArticle

Wu, Jyh Horng ; Tung, Yu Tang ; Chyu, Chiou Fung ; Chien, Shih Chang ; Wang, Sheng Yang ; Chang, Shang Tzen ; Kuo, Yueh Hsiung. / Antioxidant activity and constituents of extracts from the root of Garcinia multiflora. In: Journal of Wood Science. 2008 ; Vol. 54, No. 5. pp. 383-389.
@article{83bd0b1bca334d2c871f9dcf155c2022,
title = "Antioxidant activity and constituents of extracts from the root of Garcinia multiflora",
abstract = "The methanolic extract of the root of Garcinia multiflora and its derived soluble fractions, namely those soluble in ethyl acetate (EtOAc), n-butanol, and water, were screened for their antioxidant activities. Among them, the EtOAc-soluble fraction exhibited the highest scavenging activity against the 1,1-dipheny1,2-picrylhydrazyl radical, the highest superoxide radical scavenging activity, and the strongest reducing power. In addition, according to the bioactivity-guided isolation, 26 specific phytocompounds, including 3 aromatics, 3 benzophenones, 3 flavonoids, 3 isocoumarins, 1 phloroglucinol, 6 steroids, and 7 xanthones, were isolated from the EtOAc-soluble fraction and identified. Of these, 2,4,3′,4′-tetrahydroxy-6-methoxybenzophenone and 1,3,6,7-tetrahydroxyxanthone were found to be the major bioactive constituents, present in the crude extract in concentrations of 3.9 and 15.6 mg/g, respectively. These two compounds had similar antioxidant activities to (+)-catechin, a well-known antioxidant.",
keywords = "Antioxidant, Bioactivity-guided isolation, Garcinia multiflora, Phytocompound, Reactive oxygen species",
author = "Wu, {Jyh Horng} and Tung, {Yu Tang} and Chyu, {Chiou Fung} and Chien, {Shih Chang} and Wang, {Sheng Yang} and Chang, {Shang Tzen} and Kuo, {Yueh Hsiung}",
year = "2008",
month = "10",
doi = "10.1007/s10086-008-0961-9",
language = "English",
volume = "54",
pages = "383--389",
journal = "Journal of Wood Science",
issn = "1435-0211",
publisher = "Springer Japan",
number = "5",

}

TY - JOUR

T1 - Antioxidant activity and constituents of extracts from the root of Garcinia multiflora

AU - Wu, Jyh Horng

AU - Tung, Yu Tang

AU - Chyu, Chiou Fung

AU - Chien, Shih Chang

AU - Wang, Sheng Yang

AU - Chang, Shang Tzen

AU - Kuo, Yueh Hsiung

PY - 2008/10

Y1 - 2008/10

N2 - The methanolic extract of the root of Garcinia multiflora and its derived soluble fractions, namely those soluble in ethyl acetate (EtOAc), n-butanol, and water, were screened for their antioxidant activities. Among them, the EtOAc-soluble fraction exhibited the highest scavenging activity against the 1,1-dipheny1,2-picrylhydrazyl radical, the highest superoxide radical scavenging activity, and the strongest reducing power. In addition, according to the bioactivity-guided isolation, 26 specific phytocompounds, including 3 aromatics, 3 benzophenones, 3 flavonoids, 3 isocoumarins, 1 phloroglucinol, 6 steroids, and 7 xanthones, were isolated from the EtOAc-soluble fraction and identified. Of these, 2,4,3′,4′-tetrahydroxy-6-methoxybenzophenone and 1,3,6,7-tetrahydroxyxanthone were found to be the major bioactive constituents, present in the crude extract in concentrations of 3.9 and 15.6 mg/g, respectively. These two compounds had similar antioxidant activities to (+)-catechin, a well-known antioxidant.

AB - The methanolic extract of the root of Garcinia multiflora and its derived soluble fractions, namely those soluble in ethyl acetate (EtOAc), n-butanol, and water, were screened for their antioxidant activities. Among them, the EtOAc-soluble fraction exhibited the highest scavenging activity against the 1,1-dipheny1,2-picrylhydrazyl radical, the highest superoxide radical scavenging activity, and the strongest reducing power. In addition, according to the bioactivity-guided isolation, 26 specific phytocompounds, including 3 aromatics, 3 benzophenones, 3 flavonoids, 3 isocoumarins, 1 phloroglucinol, 6 steroids, and 7 xanthones, were isolated from the EtOAc-soluble fraction and identified. Of these, 2,4,3′,4′-tetrahydroxy-6-methoxybenzophenone and 1,3,6,7-tetrahydroxyxanthone were found to be the major bioactive constituents, present in the crude extract in concentrations of 3.9 and 15.6 mg/g, respectively. These two compounds had similar antioxidant activities to (+)-catechin, a well-known antioxidant.

KW - Antioxidant

KW - Bioactivity-guided isolation

KW - Garcinia multiflora

KW - Phytocompound

KW - Reactive oxygen species

UR - http://www.scopus.com/inward/record.url?scp=54249087032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54249087032&partnerID=8YFLogxK

U2 - 10.1007/s10086-008-0961-9

DO - 10.1007/s10086-008-0961-9

M3 - Article

AN - SCOPUS:54249087032

VL - 54

SP - 383

EP - 389

JO - Journal of Wood Science

JF - Journal of Wood Science

SN - 1435-0211

IS - 5

ER -