Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans

Chi Han Wu, Chun Hsu Pan, Ching Kuo Lee, Ming Jyh Sheu, Fon Chang Liu, Guei Jane Wang, Chieh Hsi Wu

Research output: Contribution to journalArticle

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Abstract

Yan-Sheng-Yin (YSY), a Chinese natural dietary supplement that promotes good health, is entirely composed of natural foods. Whether YSY is a potential adjuvant intervention for reducing hyperlipidaemia, atherogenesis, or obesity is unclear. This study evaluated the inhibitory effects and mechanisms of YSY for hyperlipidaemia, atherogenesis, and obesity. Experimental results showed that YSY reduced body weight, hyperlipidaemia, fatty liver, and atherogenesis in hyperlipidaemic mice. In addition, YSY promoted lipid metabolism by inducing adiponectin secretion and activation (phosphorylation) of 5' adenosine monophosphate-activated protein kinase (AMPK) and by suppressing the activation of acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR). Moreover, YSY inhibited adipocyte differentiation by suppressing peroxisome proliferator-activated receptor gamma (PPAR-γ) and CCAAT/enhancer-binding proteins (C/EBPs). Furthermore, the antihyperlipidaemic effect of YSY was observed in the clinical trial. Our findings suggest that YSY is an adjuvant intervention for treating and preventing hyperlipidaemia, atherogenesis, and obesity.

Original languageEnglish
Pages (from-to)173-182
Number of pages10
JournalJournal of Functional Foods
Volume24
DOIs
Publication statusPublished - Jun 1 2016

Fingerprint

Hypolipidemic Agents
atherogenesis
hyperlipidemia
Hyperlipidemias
Atherosclerosis
obesity
Obesity
adjuvants
animals
CCAAT-Enhancer-Binding Proteins
Hydroxymethylglutaryl CoA Reductases
Acetyl-CoA Carboxylase
AMP-activated protein kinase
acetyl-CoA carboxylase
Peroxisome Proliferator-Activated Receptors
adiponectin
PPAR gamma
Adiponectin
natural foods
fatty liver

Keywords

  • Adipocyte differentiation
  • Atherogenesis
  • Hyperlipidaemia
  • Obesity
  • Yan-Sheng-Yin

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans. / Wu, Chi Han; Pan, Chun Hsu; Lee, Ching Kuo; Sheu, Ming Jyh; Liu, Fon Chang; Wang, Guei Jane; Wu, Chieh Hsi.

In: Journal of Functional Foods, Vol. 24, 01.06.2016, p. 173-182.

Research output: Contribution to journalArticle

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