Antineoplastic activity of benzimidazo[1,2-b]-isoquinolines, indolo[2,3-b]quinolines, and pyridocarbazoles

Ronni L. Weinkauf, Allan Y. Chen, Chiang Yu, Leroy-Fong Liu, Louis Barrows, Edmond J. LaVoie

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Substituted pyrido[3,4-b]carbazoles, pyrido[2,3-b]carbazoles, indolo[2,3-b]quinolines, and benzimidazo[1,2-b]-isoquinolines were synthesized and evaluated for biological activity. Several methylated derivatives of these heterocyclic compounds had similar activity to ellipticine as mammalian topoisomerase II inhibitors. Methylated derivatives of these heterocyclic compounds were also highly active in vitro, inhibiting the growth of several human tumor cell lines. These data demonstrate that the antineoplastic activity associated with ellipticine can be retained within a wide variety of analogous heterocyclics.

Original languageEnglish
Pages (from-to)781-786
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume2
Issue number8
DOIs
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

ellipticine
Isoquinolines
Quinolines
Heterocyclic Compounds
Antineoplastic Agents
Carbazoles
Topoisomerase II Inhibitors
Tumor Cell Line
Derivatives
Bioactivity
Tumors
Growth
Cells
indolo(3,2-b)carbazole
indolo(2,3-b)quinoline

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Antineoplastic activity of benzimidazo[1,2-b]-isoquinolines, indolo[2,3-b]quinolines, and pyridocarbazoles. / Weinkauf, Ronni L.; Chen, Allan Y.; Yu, Chiang; Liu, Leroy-Fong; Barrows, Louis; LaVoie, Edmond J.

In: Bioorganic and Medicinal Chemistry, Vol. 2, No. 8, 1994, p. 781-786.

Research output: Contribution to journalArticle

Weinkauf, Ronni L. ; Chen, Allan Y. ; Yu, Chiang ; Liu, Leroy-Fong ; Barrows, Louis ; LaVoie, Edmond J. / Antineoplastic activity of benzimidazo[1,2-b]-isoquinolines, indolo[2,3-b]quinolines, and pyridocarbazoles. In: Bioorganic and Medicinal Chemistry. 1994 ; Vol. 2, No. 8. pp. 781-786.
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