Antimicrobial susceptibility of pathogens isolated from patients with complicated intra-abdominal infections at five medical centers in Taiwan that continuously participated in the Study for Monitoring Antimicrobial Resistance Trends (SMART) from 2006 to 2010

Yu Lin Lee, Yao Shen Chen, Han Siong Toh, Chi Chang Huang, Yuag Meng Liu, Cheng Mao Ho, Po Liang Lu, Wen Chien Ko, Yen Hsu Chen, Jen Hsien Wang, Hung Jen Tang, Kwok Woon Yu, Yung Ching Liu, Yin Ching Chuang, Chun Eng Liu, Po Ren Hsueh

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The Study for Monitoring Antimicrobial Resistance Trends (SMART) is a worldwide surveillance program designed to longitudinally monitor the in vitro activity of antimicrobial agents against pathogens that cause intra-abdominal infections (IAIs). In this study, trends in antimicrobial resistance during the period 2006 to 2010 were analyzed at five tertiary-care hospitals in Taiwan. Enterobacteriaceae accounted for the majority (80.9) of the 2417 Gram-negative isolates, and the two most common species were Escherichia coli (38.8) and Klebsiella pneumoniae (23.5). The rates of susceptibility of Enterobacteriaceae isolates to cephalosporins decreased during the study period. Although carbapenems, fluoroquinolones, piperacillin-tazobactam, and amikacin were active in vitro against more than 80 of the Enterobacteriaceae isolates, the activity of carbapenems declined during the study period. Extended-spectrum β-lactamase (ESBL) production in E. coli was steady, but that in K. pneumoniae decreased during the study period. The rate of ESBLproducing species was three-fold higher among patients with nosocomial IAIs than among patients with community-acquired IAIs. The majority of isolates from liver were K. pneumoniae (69) and very few of those isolates were ESBL producers (0.9). Pseudomonas aeruginosa (9.3) and Acinetobacter baumannii (3.8) were the two most common non-Enterobacteriaceae. P. aeruginosa showed improved susceptibility, whereas A. baumannii showed a rapid development of resistance during the study period. There was marked geographic variation in resistance patterns of the isolates obtained during the study period. Northern Taiwan had the highest rate of ESBL producers and the highest rate of ceftazidime resistance among P. aeruginosa isolates. Central Taiwan had the lowest rate of ESBL producers but the highest rates of carbapenem resistance among P. aeruginosa and A. baumannii isolates. Continuous monitoring and regular updates of epidemiological data are needed to guide appropriate empiric antimicrobial therapy.

Original languageEnglish
JournalInternational Journal of Antimicrobial Agents
Volume40
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Intraabdominal Infections
Taiwan
Acinetobacter baumannii
Pseudomonas aeruginosa
Carbapenems
Klebsiella pneumoniae
Enterobacteriaceae
Escherichia coli
Community-Acquired Infections
Ceftazidime
Amikacin
Fluoroquinolones
Tertiary Healthcare
Cephalosporins
Cross Infection
Anti-Infective Agents
Tertiary Care Centers
Liver
In Vitro Techniques

Keywords

  • Antimicrobial resistance
  • Enterobacteriaceae
  • Epidemiology
  • Extended-spectrum β-lactamase
  • Taiwan

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Antimicrobial susceptibility of pathogens isolated from patients with complicated intra-abdominal infections at five medical centers in Taiwan that continuously participated in the Study for Monitoring Antimicrobial Resistance Trends (SMART) from 2006 to 2010. / Lee, Yu Lin; Chen, Yao Shen; Toh, Han Siong; Huang, Chi Chang; Liu, Yuag Meng; Ho, Cheng Mao; Lu, Po Liang; Ko, Wen Chien; Chen, Yen Hsu; Wang, Jen Hsien; Tang, Hung Jen; Yu, Kwok Woon; Liu, Yung Ching; Chuang, Yin Ching; Liu, Chun Eng; Hsueh, Po Ren.

In: International Journal of Antimicrobial Agents, Vol. 40, No. SUPPL. 1, 06.2012.

Research output: Contribution to journalArticle

Lee, Yu Lin ; Chen, Yao Shen ; Toh, Han Siong ; Huang, Chi Chang ; Liu, Yuag Meng ; Ho, Cheng Mao ; Lu, Po Liang ; Ko, Wen Chien ; Chen, Yen Hsu ; Wang, Jen Hsien ; Tang, Hung Jen ; Yu, Kwok Woon ; Liu, Yung Ching ; Chuang, Yin Ching ; Liu, Chun Eng ; Hsueh, Po Ren. / Antimicrobial susceptibility of pathogens isolated from patients with complicated intra-abdominal infections at five medical centers in Taiwan that continuously participated in the Study for Monitoring Antimicrobial Resistance Trends (SMART) from 2006 to 2010. In: International Journal of Antimicrobial Agents. 2012 ; Vol. 40, No. SUPPL. 1.
@article{a37657435f114548ba5683405940e93e,
title = "Antimicrobial susceptibility of pathogens isolated from patients with complicated intra-abdominal infections at five medical centers in Taiwan that continuously participated in the Study for Monitoring Antimicrobial Resistance Trends (SMART) from 2006 to 2010",
abstract = "The Study for Monitoring Antimicrobial Resistance Trends (SMART) is a worldwide surveillance program designed to longitudinally monitor the in vitro activity of antimicrobial agents against pathogens that cause intra-abdominal infections (IAIs). In this study, trends in antimicrobial resistance during the period 2006 to 2010 were analyzed at five tertiary-care hospitals in Taiwan. Enterobacteriaceae accounted for the majority (80.9) of the 2417 Gram-negative isolates, and the two most common species were Escherichia coli (38.8) and Klebsiella pneumoniae (23.5). The rates of susceptibility of Enterobacteriaceae isolates to cephalosporins decreased during the study period. Although carbapenems, fluoroquinolones, piperacillin-tazobactam, and amikacin were active in vitro against more than 80 of the Enterobacteriaceae isolates, the activity of carbapenems declined during the study period. Extended-spectrum β-lactamase (ESBL) production in E. coli was steady, but that in K. pneumoniae decreased during the study period. The rate of ESBLproducing species was three-fold higher among patients with nosocomial IAIs than among patients with community-acquired IAIs. The majority of isolates from liver were K. pneumoniae (69) and very few of those isolates were ESBL producers (0.9). Pseudomonas aeruginosa (9.3) and Acinetobacter baumannii (3.8) were the two most common non-Enterobacteriaceae. P. aeruginosa showed improved susceptibility, whereas A. baumannii showed a rapid development of resistance during the study period. There was marked geographic variation in resistance patterns of the isolates obtained during the study period. Northern Taiwan had the highest rate of ESBL producers and the highest rate of ceftazidime resistance among P. aeruginosa isolates. Central Taiwan had the lowest rate of ESBL producers but the highest rates of carbapenem resistance among P. aeruginosa and A. baumannii isolates. Continuous monitoring and regular updates of epidemiological data are needed to guide appropriate empiric antimicrobial therapy.",
keywords = "Antimicrobial resistance, Enterobacteriaceae, Epidemiology, Extended-spectrum β-lactamase, Taiwan",
author = "Lee, {Yu Lin} and Chen, {Yao Shen} and Toh, {Han Siong} and Huang, {Chi Chang} and Liu, {Yuag Meng} and Ho, {Cheng Mao} and Lu, {Po Liang} and Ko, {Wen Chien} and Chen, {Yen Hsu} and Wang, {Jen Hsien} and Tang, {Hung Jen} and Yu, {Kwok Woon} and Liu, {Yung Ching} and Chuang, {Yin Ching} and Liu, {Chun Eng} and Hsueh, {Po Ren}",
year = "2012",
month = "6",
doi = "10.1016/S0924-8579(12)70007-9",
language = "English",
volume = "40",
journal = "International Journal of Antimicrobial Agents",
issn = "0924-8579",
publisher = "Elsevier",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Antimicrobial susceptibility of pathogens isolated from patients with complicated intra-abdominal infections at five medical centers in Taiwan that continuously participated in the Study for Monitoring Antimicrobial Resistance Trends (SMART) from 2006 to 2010

AU - Lee, Yu Lin

AU - Chen, Yao Shen

AU - Toh, Han Siong

AU - Huang, Chi Chang

AU - Liu, Yuag Meng

AU - Ho, Cheng Mao

AU - Lu, Po Liang

AU - Ko, Wen Chien

AU - Chen, Yen Hsu

AU - Wang, Jen Hsien

AU - Tang, Hung Jen

AU - Yu, Kwok Woon

AU - Liu, Yung Ching

AU - Chuang, Yin Ching

AU - Liu, Chun Eng

AU - Hsueh, Po Ren

PY - 2012/6

Y1 - 2012/6

N2 - The Study for Monitoring Antimicrobial Resistance Trends (SMART) is a worldwide surveillance program designed to longitudinally monitor the in vitro activity of antimicrobial agents against pathogens that cause intra-abdominal infections (IAIs). In this study, trends in antimicrobial resistance during the period 2006 to 2010 were analyzed at five tertiary-care hospitals in Taiwan. Enterobacteriaceae accounted for the majority (80.9) of the 2417 Gram-negative isolates, and the two most common species were Escherichia coli (38.8) and Klebsiella pneumoniae (23.5). The rates of susceptibility of Enterobacteriaceae isolates to cephalosporins decreased during the study period. Although carbapenems, fluoroquinolones, piperacillin-tazobactam, and amikacin were active in vitro against more than 80 of the Enterobacteriaceae isolates, the activity of carbapenems declined during the study period. Extended-spectrum β-lactamase (ESBL) production in E. coli was steady, but that in K. pneumoniae decreased during the study period. The rate of ESBLproducing species was three-fold higher among patients with nosocomial IAIs than among patients with community-acquired IAIs. The majority of isolates from liver were K. pneumoniae (69) and very few of those isolates were ESBL producers (0.9). Pseudomonas aeruginosa (9.3) and Acinetobacter baumannii (3.8) were the two most common non-Enterobacteriaceae. P. aeruginosa showed improved susceptibility, whereas A. baumannii showed a rapid development of resistance during the study period. There was marked geographic variation in resistance patterns of the isolates obtained during the study period. Northern Taiwan had the highest rate of ESBL producers and the highest rate of ceftazidime resistance among P. aeruginosa isolates. Central Taiwan had the lowest rate of ESBL producers but the highest rates of carbapenem resistance among P. aeruginosa and A. baumannii isolates. Continuous monitoring and regular updates of epidemiological data are needed to guide appropriate empiric antimicrobial therapy.

AB - The Study for Monitoring Antimicrobial Resistance Trends (SMART) is a worldwide surveillance program designed to longitudinally monitor the in vitro activity of antimicrobial agents against pathogens that cause intra-abdominal infections (IAIs). In this study, trends in antimicrobial resistance during the period 2006 to 2010 were analyzed at five tertiary-care hospitals in Taiwan. Enterobacteriaceae accounted for the majority (80.9) of the 2417 Gram-negative isolates, and the two most common species were Escherichia coli (38.8) and Klebsiella pneumoniae (23.5). The rates of susceptibility of Enterobacteriaceae isolates to cephalosporins decreased during the study period. Although carbapenems, fluoroquinolones, piperacillin-tazobactam, and amikacin were active in vitro against more than 80 of the Enterobacteriaceae isolates, the activity of carbapenems declined during the study period. Extended-spectrum β-lactamase (ESBL) production in E. coli was steady, but that in K. pneumoniae decreased during the study period. The rate of ESBLproducing species was three-fold higher among patients with nosocomial IAIs than among patients with community-acquired IAIs. The majority of isolates from liver were K. pneumoniae (69) and very few of those isolates were ESBL producers (0.9). Pseudomonas aeruginosa (9.3) and Acinetobacter baumannii (3.8) were the two most common non-Enterobacteriaceae. P. aeruginosa showed improved susceptibility, whereas A. baumannii showed a rapid development of resistance during the study period. There was marked geographic variation in resistance patterns of the isolates obtained during the study period. Northern Taiwan had the highest rate of ESBL producers and the highest rate of ceftazidime resistance among P. aeruginosa isolates. Central Taiwan had the lowest rate of ESBL producers but the highest rates of carbapenem resistance among P. aeruginosa and A. baumannii isolates. Continuous monitoring and regular updates of epidemiological data are needed to guide appropriate empiric antimicrobial therapy.

KW - Antimicrobial resistance

KW - Enterobacteriaceae

KW - Epidemiology

KW - Extended-spectrum β-lactamase

KW - Taiwan

UR - http://www.scopus.com/inward/record.url?scp=84863480757&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863480757&partnerID=8YFLogxK

U2 - 10.1016/S0924-8579(12)70007-9

DO - 10.1016/S0924-8579(12)70007-9

M3 - Article

C2 - 22749056

AN - SCOPUS:84863480757

VL - 40

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

SN - 0924-8579

IS - SUPPL. 1

ER -