Antimicrobial Gold Nanoclusters: Recent Developments and Future Perspectives

Sibidou Yougbare, Ting Kuang Chang, Shih Hua Tan, Jui Chi Kuo, Po Hsuan Hsu, Chen Yen Su, Tsung Rong Kuo

Research output: Contribution to journalReview article

Abstract

Bacterial infections have caused serious threats to public health due to the antimicrobial resistance in bacteria. Recently, gold nanoclusters (AuNCs) have been extensively investigated for biomedical applications because of their superior structural and optical properties. Great efforts have demonstrated that AuNCs conjugated with various surface ligands are promising antimicrobial agents owing to their high biocompatibility, polyvalent effect, easy modification and photothermal stability. In this review, we have highlighted the recent achievements for the utilizations of AuNCs as the antimicrobial agents. We have classified the antimicrobial AuNCs by their surface ligands including small molecules (< 900 Daltons) and macromolecules (> 900 Daltons). Moreover, the antimicrobial activities and mechanisms of AuNCs have been introduced into two main categories of small molecules and macromolecules, respectively. In accordance with the advancements of antimicrobial AuNCs, we further provided conclusions of current challenges and recommendations of future perspectives of antimicrobial AuNCs for fundamental researches and clinical applications.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume20
Issue number12
DOIs
Publication statusPublished - Jun 14 2019

Fingerprint

Antimicrobial agents
Nanoclusters
Anti-Infective Agents
nanoclusters
Gold
Ligands
gold
Molecules
Public health
Macromolecules
Biocompatibility
Bacterial Infections
Structural properties
public health
Bacteria
ligands
Optical properties
Public Health
biocompatibility
infectious diseases

Keywords

  • antimicrobial agent
  • antimicrobial mechanism
  • gold nanoclusters
  • macromolecule
  • small molecule

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Antimicrobial Gold Nanoclusters : Recent Developments and Future Perspectives. / Yougbare, Sibidou; Chang, Ting Kuang; Tan, Shih Hua; Kuo, Jui Chi; Hsu, Po Hsuan; Su, Chen Yen; Kuo, Tsung Rong.

In: International Journal of Molecular Sciences, Vol. 20, No. 12, 14.06.2019.

Research output: Contribution to journalReview article

Yougbare, Sibidou ; Chang, Ting Kuang ; Tan, Shih Hua ; Kuo, Jui Chi ; Hsu, Po Hsuan ; Su, Chen Yen ; Kuo, Tsung Rong. / Antimicrobial Gold Nanoclusters : Recent Developments and Future Perspectives. In: International Journal of Molecular Sciences. 2019 ; Vol. 20, No. 12.
@article{974bb065f3634202ace1569f0b7646e1,
title = "Antimicrobial Gold Nanoclusters: Recent Developments and Future Perspectives",
abstract = "Bacterial infections have caused serious threats to public health due to the antimicrobial resistance in bacteria. Recently, gold nanoclusters (AuNCs) have been extensively investigated for biomedical applications because of their superior structural and optical properties. Great efforts have demonstrated that AuNCs conjugated with various surface ligands are promising antimicrobial agents owing to their high biocompatibility, polyvalent effect, easy modification and photothermal stability. In this review, we have highlighted the recent achievements for the utilizations of AuNCs as the antimicrobial agents. We have classified the antimicrobial AuNCs by their surface ligands including small molecules (< 900 Daltons) and macromolecules (> 900 Daltons). Moreover, the antimicrobial activities and mechanisms of AuNCs have been introduced into two main categories of small molecules and macromolecules, respectively. In accordance with the advancements of antimicrobial AuNCs, we further provided conclusions of current challenges and recommendations of future perspectives of antimicrobial AuNCs for fundamental researches and clinical applications.",
keywords = "antimicrobial agent, antimicrobial mechanism, gold nanoclusters, macromolecule, small molecule",
author = "Sibidou Yougbare and Chang, {Ting Kuang} and Tan, {Shih Hua} and Kuo, {Jui Chi} and Hsu, {Po Hsuan} and Su, {Chen Yen} and Kuo, {Tsung Rong}",
year = "2019",
month = "6",
day = "14",
doi = "10.3390/ijms20122924",
language = "English",
volume = "20",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "12",

}

TY - JOUR

T1 - Antimicrobial Gold Nanoclusters

T2 - Recent Developments and Future Perspectives

AU - Yougbare, Sibidou

AU - Chang, Ting Kuang

AU - Tan, Shih Hua

AU - Kuo, Jui Chi

AU - Hsu, Po Hsuan

AU - Su, Chen Yen

AU - Kuo, Tsung Rong

PY - 2019/6/14

Y1 - 2019/6/14

N2 - Bacterial infections have caused serious threats to public health due to the antimicrobial resistance in bacteria. Recently, gold nanoclusters (AuNCs) have been extensively investigated for biomedical applications because of their superior structural and optical properties. Great efforts have demonstrated that AuNCs conjugated with various surface ligands are promising antimicrobial agents owing to their high biocompatibility, polyvalent effect, easy modification and photothermal stability. In this review, we have highlighted the recent achievements for the utilizations of AuNCs as the antimicrobial agents. We have classified the antimicrobial AuNCs by their surface ligands including small molecules (< 900 Daltons) and macromolecules (> 900 Daltons). Moreover, the antimicrobial activities and mechanisms of AuNCs have been introduced into two main categories of small molecules and macromolecules, respectively. In accordance with the advancements of antimicrobial AuNCs, we further provided conclusions of current challenges and recommendations of future perspectives of antimicrobial AuNCs for fundamental researches and clinical applications.

AB - Bacterial infections have caused serious threats to public health due to the antimicrobial resistance in bacteria. Recently, gold nanoclusters (AuNCs) have been extensively investigated for biomedical applications because of their superior structural and optical properties. Great efforts have demonstrated that AuNCs conjugated with various surface ligands are promising antimicrobial agents owing to their high biocompatibility, polyvalent effect, easy modification and photothermal stability. In this review, we have highlighted the recent achievements for the utilizations of AuNCs as the antimicrobial agents. We have classified the antimicrobial AuNCs by their surface ligands including small molecules (< 900 Daltons) and macromolecules (> 900 Daltons). Moreover, the antimicrobial activities and mechanisms of AuNCs have been introduced into two main categories of small molecules and macromolecules, respectively. In accordance with the advancements of antimicrobial AuNCs, we further provided conclusions of current challenges and recommendations of future perspectives of antimicrobial AuNCs for fundamental researches and clinical applications.

KW - antimicrobial agent

KW - antimicrobial mechanism

KW - gold nanoclusters

KW - macromolecule

KW - small molecule

UR - http://www.scopus.com/inward/record.url?scp=85068366374&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068366374&partnerID=8YFLogxK

U2 - 10.3390/ijms20122924

DO - 10.3390/ijms20122924

M3 - Review article

C2 - 31208013

AN - SCOPUS:85068366374

VL - 20

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 12

ER -