Antimetastatic effects of cordycepin mediated by the inhibition of mitochondrial activity and estrogen-related receptor a in human ovarian carcinoma cells

Chia Woei Wang, Wei Hsuan Hsu, Chen Jei Tai

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Cordycepin (3'-deoxyadenosine) is a compound for antitumor, which has been found to exert antiangiogenic, antimetastatic, and antiproliferative effects, as well as inducing apoptosis. However, the association between cancer metastasis and mitochondrial activity in cordycepin-treated ovarian carcinoma cells remains unclear. The 50 and 100 μM of cordycepin inhibits mitochondrial fusion and induces mitochondrial fission, respectively. These suggested that cordycepin showed the down-regulation of mitochondrial function and limitation of energy production. Because of activation of mitochondria and generation of energy are needed in cancer cell migration/invasion. After 24 h treatment, cordycepin suppresses epithelial-mesenchymal transition and migration in ovarian carcinoma cells through inhibiting estrogen-related receptor (ERR)-α. The ERRa is a co-transcription factor for gene expressions associated with mitochondrial fusion. Our results indicate that cordycepin suppresses metastasis and migration of ovarian carcinoma cells via inhibiting mitochondrial activity in non-toxic concentrations, and cordycepin has potential benefits in ovarian cancer therapy.

Original languageEnglish
Pages (from-to)3049-3058
Number of pages10
JournalOncotarget
Volume8
Issue number2
DOIs
Publication statusPublished - 2017

Keywords

  • Antimigration
  • Cordycepin
  • Estrogen-related receptor (ERR)-α
  • Mitochondrial fission
  • Mitochondrial fusion

ASJC Scopus subject areas

  • Oncology

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