Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats

Kunio Suetsuna, Keisei Maekawa, Jiun Rong Chen

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

We examined the angiotensin I-converting enzyme (ACE) inhibitory activity and antihypertensive effect of the hot water extract of wakame, Undaria pinnatifida. Ten dipeptides were isolated from the extract by several steps of chromatography, and their amino acid sequences were Tyr-His, Lys-Trp, Lys-Tyr, Lys-Phe, Phe-Tyr, Val-Trp, Val-Phe, Ile-Tyr, Ile-Trp, and Val-Tyr. Both single administration and repeated oral administration of synthetic Tyr-His, Lys-Tyr, Phe-Tyr, and Ile-Tyr significantly decreased blood pressure in spontaneously hypertensive rats.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalJournal of Nutritional Biochemistry
Volume15
Issue number5
DOIs
Publication statusPublished - May 2004

Fingerprint

isoleucyl-tyrosine
Undaria
Blood pressure
Inbred SHR Rats
N-valyltryptophan
N2-tryptophyllysine
valyltyrosine
lysylphenylalanine
Antihypertensive Agents
Rats
Blood Pressure
Peptides
Dipeptides
Enzyme activity
Peptidyl-Dipeptidase A
Chromatography
Oral Administration
Amino Acid Sequence
Amino Acids
Water

Keywords

  • Angiotensin converting enzyme
  • blood pressure
  • Dipeptide
  • Hot water extract
  • Wakame

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats. / Suetsuna, Kunio; Maekawa, Keisei; Chen, Jiun Rong.

In: Journal of Nutritional Biochemistry, Vol. 15, No. 5, 05.2004, p. 267-272.

Research output: Contribution to journalArticle

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