Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats

Kunio Suetsuna, Keisei Maekawa, Jiun Rong Chen

Research output: Contribution to journalArticle

150 Citations (Scopus)


We examined the angiotensin I-converting enzyme (ACE) inhibitory activity and antihypertensive effect of the hot water extract of wakame, Undaria pinnatifida. Ten dipeptides were isolated from the extract by several steps of chromatography, and their amino acid sequences were Tyr-His, Lys-Trp, Lys-Tyr, Lys-Phe, Phe-Tyr, Val-Trp, Val-Phe, Ile-Tyr, Ile-Trp, and Val-Tyr. Both single administration and repeated oral administration of synthetic Tyr-His, Lys-Tyr, Phe-Tyr, and Ile-Tyr significantly decreased blood pressure in spontaneously hypertensive rats.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalJournal of Nutritional Biochemistry
Issue number5
Publication statusPublished - May 2004



  • Angiotensin converting enzyme
  • blood pressure
  • Dipeptide
  • Hot water extract
  • Wakame

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this