Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiontensin converting enzyme

Ju Chi Liu, Feng-Lin Hsu, Jen Chen Tsai, Paul Chan, Jenny Ya Hsin Liu, G. Neil Thomas, Brian Tomlinson, Ming Yu Lo, Jung Yaw Lin

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

The tannins are natural polyphenols, able to precipitate water-soluble alkaloids and possess an inhibitory action on the angiotensin converting enzyme (ACE). We identified 18 polyphenolic compounds (tannins) from Chinese herbs and examined the in vitro effects of these tannins on ACE activity, including determination of the 50% inhibitory concentrations (IC 50), specificity and mode of inhibition. We also assessed the in vivo inhibitory effect of the tannins on angiotensin I-induced blood pressure elevation in spontaneously hypertensive rats (SHR). Nine tannins with an IC 50

Original languageEnglish
Pages (from-to)1543-1555
Number of pages13
JournalLife Sciences
Volume73
Issue number12
DOIs
Publication statusPublished - Aug 8 2003

Keywords

  • Angiotensin converting enzyme
  • Inhibitor
  • Tannins
  • Traditional Chinese herbs

ASJC Scopus subject areas

  • Pharmacology

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