Antihypertensive effects of Hsian-tsao and its active compound in spontaneously hypertensive rats

Chi Tai Yeh, Wen Hua Huang, Gow Chin Yen

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The present study aimed to investigate the effects of Hsian-tsao (Mesona procumbens Hemsl.) and its active compound on blood pressure, lipid peroxidation and total antioxidant status of spontaneously hypertensive rats (SHRs). Male SHRs were orally administrated either a water extract of Hsian-tsao (WEHT) (1.0 g/kg) or caffeic acid (CA) [0.1 g/kg of body weight (BW)] on a daily basis for 6 weeks. The results indicated that both hepatic and plasmatic malondialdehyde concentration were increased and total liver glutathione (GSH) levels and antioxidant enzyme activities were decreased in SHRs when compared to the control Wistar Kyoto rats at the end of the trail. In SHRs, oral administration of WEHT or CA for 6 weeks reduced blood pressure as well as plasma and hepatic malondialdehyde levels and increased hepatic antioxidant enzyme activities when compared to SHRs control rats. Reverse transcriptase-polymerase chain reaction results indicated that the changes in hepatic antioxidant enzyme mRNA levels by WEHT or CA were similar to those noted in the enzyme activity levels. The hepatic levels obtained from WEHT or CA-administrated rats had significantly greater oxygen radical absorbance capacity values and total GSH levels than those of control rats. Following oral administration of CA, phenolic acid was detected in the plasma, and Cmax value after 1.0 h administration was 0.92 μmol/L. These findings indicate that a supplement of Hsian-tsao may prevent development of increased blood pressure and enhance the total antioxidant status in vivo.
Original languageEnglish
Pages (from-to)866-875
Number of pages10
JournalJournal of Nutritional Biochemistry
Volume20
Issue number11
DOIs
Publication statusPublished - Nov 1 2009
Externally publishedYes

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Inbred SHR Rats
Antihypertensive Agents
Rats
Antioxidants
Liver
Blood pressure
Enzyme activity
Rat control
Water
Enzymes
Blood Pressure
Malondialdehyde
Oral Administration
Lamiaceae
Inbred WKY Rats
Plasmas
Reverse Transcriptase Polymerase Chain Reaction
Polymerase chain reaction
RNA-Directed DNA Polymerase
Lipid Peroxidation

Keywords

  • Antihypertension
  • Caffeic acid
  • Mesona procumbens
  • Spontaneously hypertensive rats

Cite this

Antihypertensive effects of Hsian-tsao and its active compound in spontaneously hypertensive rats. / Yeh, Chi Tai; Huang, Wen Hua; Yen, Gow Chin.

In: Journal of Nutritional Biochemistry, Vol. 20, No. 11, 01.11.2009, p. 866-875.

Research output: Contribution to journalArticle

Yeh, Chi Tai ; Huang, Wen Hua ; Yen, Gow Chin. / Antihypertensive effects of Hsian-tsao and its active compound in spontaneously hypertensive rats. In: Journal of Nutritional Biochemistry. 2009 ; Vol. 20, No. 11. pp. 866-875.
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