Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats

Feng Lin Hsu, I. Min Liu, Daih Huang Kuo, Wang Chuan Chen, Hui Chen Su, Juei Tang Cheng

Research output: Contribution to journalArticle

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Abstract

The antihyperglycemic action of puerarin, purified from the roots of Pueraria lobata, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). Bolus intravenous injection of puerarin decreased the plasma glucose concentrations in a dose-dependent manner in STZ-diabetic rats. Similar treatment with puerarin also decreased the plasma glucose in normal rats, although the effect was not as great as that in STZ-diabetic rats. Puerarin at the effective dose (15.0 mg/kg) significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. In the isolated soleus muscle of STZ-diabetic rats, puerarin enhanced the uptake of radioactive glucose in a concentration-dependent manner. Moreover, the mRNA and protein levels of the subtype 4 form of glucose transporter (GLUT4) in soleus muscle were increased after repeated intravenous administration of puerarin in STZ-diabetic rats for 3 days. These results suggest that puerarin can increase the glucose utilization to lower plasma glucose in diabetic rats lacking insulin.

Original languageEnglish
Pages (from-to)788-792
Number of pages5
JournalJournal of Natural Products
Volume66
Issue number6
Publication statusPublished - Jun 1 2003

Fingerprint

glycemic effect
streptozotocin
Streptozocin
Hypoglycemic Agents
Rats
Glucose
rats
glucose
Plasmas
intravenous injection
Muscle
Skeletal Muscle
Pueraria
hypoglycemic agents
Pueraria montana var. lobata
muscles
glucose transporters
Facilitative Glucose Transport Proteins
puerarin
dosage

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Hsu, F. L., Liu, I. M., Kuo, D. H., Chen, W. C., Su, H. C., & Cheng, J. T. (2003). Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. Journal of Natural Products, 66(6), 788-792.

Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. / Hsu, Feng Lin; Liu, I. Min; Kuo, Daih Huang; Chen, Wang Chuan; Su, Hui Chen; Cheng, Juei Tang.

In: Journal of Natural Products, Vol. 66, No. 6, 01.06.2003, p. 788-792.

Research output: Contribution to journalArticle

Hsu, FL, Liu, IM, Kuo, DH, Chen, WC, Su, HC & Cheng, JT 2003, 'Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats', Journal of Natural Products, vol. 66, no. 6, pp. 788-792.
Hsu FL, Liu IM, Kuo DH, Chen WC, Su HC, Cheng JT. Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. Journal of Natural Products. 2003 Jun 1;66(6):788-792.
Hsu, Feng Lin ; Liu, I. Min ; Kuo, Daih Huang ; Chen, Wang Chuan ; Su, Hui Chen ; Cheng, Juei Tang. / Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. In: Journal of Natural Products. 2003 ; Vol. 66, No. 6. pp. 788-792.
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