Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats

Wei Jan Huang, Ho Shan Niu, Mei Hsiang Lin, Juei Tang Cheng, Feng-Lin Hsu

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The antihyperglycemic effect of catalpol (1) purified from the roots of Rehmannia glutinosa was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats) representing insulin-dependent diabetes mellitus. Bolus intravenous injection of 1 showed antihyperglycemic activity in a dose-dependent manner in STZ-diabetic rats. An effective dose of 0.1 mg/kg 1 significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. Catalpol enhanced the uptake of radioactive glucose in the isolated soleus muscle of STZ-diabetic rats in a concentration-related manner. Moreover, an effect by 1 was established on glycogen incorporation in hepatocytes isolated from STZ-diabetic rats. Catalpol was found to increase glycogen synthesis in STZ-diabetic rats. These results suggest that 1 can increase glucose utilization to lower plasma glucose in diabetic rats lacking insulin.

Original languageEnglish
Pages (from-to)1170-1172
Number of pages3
JournalJournal of Natural Products
Volume73
Issue number6
DOIs
Publication statusPublished - Jun 25 2010

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

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