Antihyperglycemic action of isoferulic acid in streptozotocin-induced diabetic rats

I. Min Liu, Feng Lin Hsu, Chieh Fu Chen, Juei Tang Cheng

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

1. Wistar rats with streptozotocin-induced diabetes (STZ-diabetic rats), which is similar to human insulin-dependent diabetic mellitus (IDDM), were employed to investigate the antihyperglycemic action of isoferulic acid. 2. A single intravenous injection of isoferulic acid decreased the plasma glucose in a dose-dependent manner in the STZ-diabetic rats. Repeated intravenous administration of STZ-diabetic rats with isoferulic acid (5.0 mg kg -1) also resulted in the lowering of plasma glucose after one day. 3. Stimulatory effects of isoferulic acid on the glucose uptake and glycogen synthesis in soleus muscles isolated from STZ-diabetic rats were also obtained indicating an increase of glucose utilization following isoferulic acid treatment which was not dependent on insulin. 4. The mRNA level of glucose transporter subtype 4 form (GLUT4) in soleus muscle was raised by isoferulic acid after repeated treatment for 1 day in STZ-diabetic rats. Similar repeated treatment with isoferulic acid reversed the elevated mRNA level of phosphoenolpyruvate carboxykinase (PEPCK) in liver of STZ-diabetic rats to the normal level. However, expression of GLUT4 and PEPCK genes in nondiabetic rats were not influenced by similar treatment with isoferulic acid. 5. These results suggest that isoferulic acid can inhibit hepatic gluconeogenesis and/or increase the glucose utilization in peripheral tissue to lower plasma glucose in diabetic rats lacking insulin.

Original languageEnglish
Pages (from-to)631-636
Number of pages6
JournalBritish Journal of Pharmacology
Volume129
Issue number4
Publication statusPublished - 2000

Fingerprint

Streptozocin
Hypoglycemic Agents
Glucose
Phosphoenolpyruvate
Facilitative Glucose Transport Proteins
Insulin
Skeletal Muscle
isoferulic acid
Messenger RNA
Gluconeogenesis
Experimental Diabetes Mellitus
Liver
Therapeutics
Glycogen
Intravenous Injections
Intravenous Administration
Wistar Rats

Keywords

  • Glucose uptake
  • Glycogen synthesis
  • Isoferulic acid
  • Skeletal muscle

ASJC Scopus subject areas

  • Pharmacology

Cite this

Liu, I. M., Hsu, F. L., Chen, C. F., & Cheng, J. T. (2000). Antihyperglycemic action of isoferulic acid in streptozotocin-induced diabetic rats. British Journal of Pharmacology, 129(4), 631-636.

Antihyperglycemic action of isoferulic acid in streptozotocin-induced diabetic rats. / Liu, I. Min; Hsu, Feng Lin; Chen, Chieh Fu; Cheng, Juei Tang.

In: British Journal of Pharmacology, Vol. 129, No. 4, 2000, p. 631-636.

Research output: Contribution to journalArticle

Liu, IM, Hsu, FL, Chen, CF & Cheng, JT 2000, 'Antihyperglycemic action of isoferulic acid in streptozotocin-induced diabetic rats', British Journal of Pharmacology, vol. 129, no. 4, pp. 631-636.
Liu, I. Min ; Hsu, Feng Lin ; Chen, Chieh Fu ; Cheng, Juei Tang. / Antihyperglycemic action of isoferulic acid in streptozotocin-induced diabetic rats. In: British Journal of Pharmacology. 2000 ; Vol. 129, No. 4. pp. 631-636.
@article{756e864271644ebfb5a1c699675c1bd8,
title = "Antihyperglycemic action of isoferulic acid in streptozotocin-induced diabetic rats",
abstract = "1. Wistar rats with streptozotocin-induced diabetes (STZ-diabetic rats), which is similar to human insulin-dependent diabetic mellitus (IDDM), were employed to investigate the antihyperglycemic action of isoferulic acid. 2. A single intravenous injection of isoferulic acid decreased the plasma glucose in a dose-dependent manner in the STZ-diabetic rats. Repeated intravenous administration of STZ-diabetic rats with isoferulic acid (5.0 mg kg -1) also resulted in the lowering of plasma glucose after one day. 3. Stimulatory effects of isoferulic acid on the glucose uptake and glycogen synthesis in soleus muscles isolated from STZ-diabetic rats were also obtained indicating an increase of glucose utilization following isoferulic acid treatment which was not dependent on insulin. 4. The mRNA level of glucose transporter subtype 4 form (GLUT4) in soleus muscle was raised by isoferulic acid after repeated treatment for 1 day in STZ-diabetic rats. Similar repeated treatment with isoferulic acid reversed the elevated mRNA level of phosphoenolpyruvate carboxykinase (PEPCK) in liver of STZ-diabetic rats to the normal level. However, expression of GLUT4 and PEPCK genes in nondiabetic rats were not influenced by similar treatment with isoferulic acid. 5. These results suggest that isoferulic acid can inhibit hepatic gluconeogenesis and/or increase the glucose utilization in peripheral tissue to lower plasma glucose in diabetic rats lacking insulin.",
keywords = "Glucose uptake, Glycogen synthesis, Isoferulic acid, Skeletal muscle",
author = "Liu, {I. Min} and Hsu, {Feng Lin} and Chen, {Chieh Fu} and Cheng, {Juei Tang}",
year = "2000",
language = "English",
volume = "129",
pages = "631--636",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Antihyperglycemic action of isoferulic acid in streptozotocin-induced diabetic rats

AU - Liu, I. Min

AU - Hsu, Feng Lin

AU - Chen, Chieh Fu

AU - Cheng, Juei Tang

PY - 2000

Y1 - 2000

N2 - 1. Wistar rats with streptozotocin-induced diabetes (STZ-diabetic rats), which is similar to human insulin-dependent diabetic mellitus (IDDM), were employed to investigate the antihyperglycemic action of isoferulic acid. 2. A single intravenous injection of isoferulic acid decreased the plasma glucose in a dose-dependent manner in the STZ-diabetic rats. Repeated intravenous administration of STZ-diabetic rats with isoferulic acid (5.0 mg kg -1) also resulted in the lowering of plasma glucose after one day. 3. Stimulatory effects of isoferulic acid on the glucose uptake and glycogen synthesis in soleus muscles isolated from STZ-diabetic rats were also obtained indicating an increase of glucose utilization following isoferulic acid treatment which was not dependent on insulin. 4. The mRNA level of glucose transporter subtype 4 form (GLUT4) in soleus muscle was raised by isoferulic acid after repeated treatment for 1 day in STZ-diabetic rats. Similar repeated treatment with isoferulic acid reversed the elevated mRNA level of phosphoenolpyruvate carboxykinase (PEPCK) in liver of STZ-diabetic rats to the normal level. However, expression of GLUT4 and PEPCK genes in nondiabetic rats were not influenced by similar treatment with isoferulic acid. 5. These results suggest that isoferulic acid can inhibit hepatic gluconeogenesis and/or increase the glucose utilization in peripheral tissue to lower plasma glucose in diabetic rats lacking insulin.

AB - 1. Wistar rats with streptozotocin-induced diabetes (STZ-diabetic rats), which is similar to human insulin-dependent diabetic mellitus (IDDM), were employed to investigate the antihyperglycemic action of isoferulic acid. 2. A single intravenous injection of isoferulic acid decreased the plasma glucose in a dose-dependent manner in the STZ-diabetic rats. Repeated intravenous administration of STZ-diabetic rats with isoferulic acid (5.0 mg kg -1) also resulted in the lowering of plasma glucose after one day. 3. Stimulatory effects of isoferulic acid on the glucose uptake and glycogen synthesis in soleus muscles isolated from STZ-diabetic rats were also obtained indicating an increase of glucose utilization following isoferulic acid treatment which was not dependent on insulin. 4. The mRNA level of glucose transporter subtype 4 form (GLUT4) in soleus muscle was raised by isoferulic acid after repeated treatment for 1 day in STZ-diabetic rats. Similar repeated treatment with isoferulic acid reversed the elevated mRNA level of phosphoenolpyruvate carboxykinase (PEPCK) in liver of STZ-diabetic rats to the normal level. However, expression of GLUT4 and PEPCK genes in nondiabetic rats were not influenced by similar treatment with isoferulic acid. 5. These results suggest that isoferulic acid can inhibit hepatic gluconeogenesis and/or increase the glucose utilization in peripheral tissue to lower plasma glucose in diabetic rats lacking insulin.

KW - Glucose uptake

KW - Glycogen synthesis

KW - Isoferulic acid

KW - Skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=0034020385&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034020385&partnerID=8YFLogxK

M3 - Article

C2 - 10683186

AN - SCOPUS:0034020385

VL - 129

SP - 631

EP - 636

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - 4

ER -