Antihepatotoxic activity of phenolic flavan-3-ols and their derivatives.

F. L. Hsu, Y. J. Tsai, M. C. Kao, C. F. Chen

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The protective activity against carbon tetrachloride induced hepatotoxicity of several phenolic flavan-3-ols and their derivatives has been assessed. Our research showed that monomers possessing a pyrogallol moiety as the B-ring had greater activity and this was not directly related to the stereo-chemistry of the hydroxyl group at C-3 in the flavan unit. However, when a galloyl group was linked to the hydroxyl group to form a gallate, this product exhibited markedly more activity than other analogs. These results suggest that the antihepatotoxic activity of phenolic flavan-3-ols and their derivatives seem to be related to the galloylation at the C-3 hydroxyl group in the flavan skeleton rather than the structure of another moiety or the degree of condensation.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalAmerican Journal of Chinese Medicine
Volume21
Issue number1
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Complementary and alternative medicine

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