Antihepatotoxic activity of phenolic flavan-3-ols and their derivatives.

F. L. Hsu, Y. J. Tsai, M. C. Kao, C. F. Chen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The protective activity against carbon tetrachloride induced hepatotoxicity of several phenolic flavan-3-ols and their derivatives has been assessed. Our research showed that monomers possessing a pyrogallol moiety as the B-ring had greater activity and this was not directly related to the stereo-chemistry of the hydroxyl group at C-3 in the flavan unit. However, when a galloyl group was linked to the hydroxyl group to form a gallate, this product exhibited markedly more activity than other analogs. These results suggest that the antihepatotoxic activity of phenolic flavan-3-ols and their derivatives seem to be related to the galloylation at the C-3 hydroxyl group in the flavan skeleton rather than the structure of another moiety or the degree of condensation.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalAmerican Journal of Chinese Medicine
Volume21
Issue number1
Publication statusPublished - 1993

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Hydroxyl Radical
Pyrogallol
Carbon Tetrachloride
Skeleton
Research

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Hsu, F. L., Tsai, Y. J., Kao, M. C., & Chen, C. F. (1993). Antihepatotoxic activity of phenolic flavan-3-ols and their derivatives. American Journal of Chinese Medicine, 21(1), 45-50.

Antihepatotoxic activity of phenolic flavan-3-ols and their derivatives. / Hsu, F. L.; Tsai, Y. J.; Kao, M. C.; Chen, C. F.

In: American Journal of Chinese Medicine, Vol. 21, No. 1, 1993, p. 45-50.

Research output: Contribution to journalArticle

Hsu, FL, Tsai, YJ, Kao, MC & Chen, CF 1993, 'Antihepatotoxic activity of phenolic flavan-3-ols and their derivatives.', American Journal of Chinese Medicine, vol. 21, no. 1, pp. 45-50.
Hsu, F. L. ; Tsai, Y. J. ; Kao, M. C. ; Chen, C. F. / Antihepatotoxic activity of phenolic flavan-3-ols and their derivatives. In: American Journal of Chinese Medicine. 1993 ; Vol. 21, No. 1. pp. 45-50.
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