Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis

Julia Yu Fong Chang, Chun Pin Chiang, Yi Ping Wang, Yang Che Wu, Hsin Ming Chen, Andy Sun

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: Desquamative gingivitis (DG) is principally associated with erosive oral lichen planus (EOLP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV). Methods: Serum autoantibodies including antigastric parietal cell antibody (GPCA), antithyroglobulin antibody (TGA), and antithyroid microsomal antibody (TMA) were measured in 500 patients with DG, 287 EOLP without DG (EOLP/DG ) patients, and 100 healthy control subjects. Results: The 500 patients with DG were diagnosed as having EOLP in 455 (91%), PV in 40 (8%), and MMP in five (1%) patients. We found that 37.0%, 43.6%, and 42.6% of 500 patients with DG, 39.6%, 46.4%, and 45.1% of 455 EOLP with DG (EOLP/DG) patients, and 18.5%, 27.5%, and 30.3% of 287 EOLP/DG patients had the presence of GPCA, TGA, and TMA in their sera, respectively. DG, EOLP/DG, and EOLP/DG patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). Moreover, 455 EOLP/DG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than 287 EOLP/DG patients (all P-values < 0.001). Of 210 TGA/TMA-positive patients with DG whose serum thyroid-stimulating hormone (TSH) levels were measured, 84.3%, 6.7%, and 9.0% patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: We conclude that 73.4% DG, 77.1% EOLP/DG, and 47.4% EOLP/DG patients may have GPCA/TGA/TMA positivity in their sera. Because part of GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive patients may have thyroid dysfunction, these patients should be referred to medical department for further management.

Original languageEnglish
Pages (from-to)307-312
Number of pages6
JournalJournal of Oral Pathology and Medicine
Volume46
Issue number4
DOIs
Publication statusPublished - Apr 1 2017
Externally publishedYes

Fingerprint

Gingivitis
Oral Lichen Planus
Autoantibodies
Antibodies
Bullous Pemphigoid
Serum
Pemphigus
Thyrotropin
Healthy Volunteers
Mucous Membrane
Atrophic Gastritis
Pernicious Anemia

Keywords

  • antigastric parietal cell antibody
  • antithyroglobulin antibody
  • antithyroid microsomal antibody
  • desquamative gingivitis
  • erosive oral lichen planus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

Cite this

Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis. / Chang, Julia Yu Fong; Chiang, Chun Pin; Wang, Yi Ping; Wu, Yang Che; Chen, Hsin Ming; Sun, Andy.

In: Journal of Oral Pathology and Medicine, Vol. 46, No. 4, 01.04.2017, p. 307-312.

Research output: Contribution to journalArticle

Chang, Julia Yu Fong ; Chiang, Chun Pin ; Wang, Yi Ping ; Wu, Yang Che ; Chen, Hsin Ming ; Sun, Andy. / Antigastric parietal cell and antithyroid autoantibodies in patients with desquamative gingivitis. In: Journal of Oral Pathology and Medicine. 2017 ; Vol. 46, No. 4. pp. 307-312.
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abstract = "Background: Desquamative gingivitis (DG) is principally associated with erosive oral lichen planus (EOLP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV). Methods: Serum autoantibodies including antigastric parietal cell antibody (GPCA), antithyroglobulin antibody (TGA), and antithyroid microsomal antibody (TMA) were measured in 500 patients with DG, 287 EOLP without DG (EOLP/DG − ) patients, and 100 healthy control subjects. Results: The 500 patients with DG were diagnosed as having EOLP in 455 (91{\%}), PV in 40 (8{\%}), and MMP in five (1{\%}) patients. We found that 37.0{\%}, 43.6{\%}, and 42.6{\%} of 500 patients with DG, 39.6{\%}, 46.4{\%}, and 45.1{\%} of 455 EOLP with DG (EOLP/DG) patients, and 18.5{\%}, 27.5{\%}, and 30.3{\%} of 287 EOLP/DG − patients had the presence of GPCA, TGA, and TMA in their sera, respectively. DG, EOLP/DG, and EOLP/DG − patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). Moreover, 455 EOLP/DG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than 287 EOLP/DG − patients (all P-values < 0.001). Of 210 TGA/TMA-positive patients with DG whose serum thyroid-stimulating hormone (TSH) levels were measured, 84.3{\%}, 6.7{\%}, and 9.0{\%} patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: We conclude that 73.4{\%} DG, 77.1{\%} EOLP/DG, and 47.4{\%} EOLP/DG − patients may have GPCA/TGA/TMA positivity in their sera. Because part of GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive patients may have thyroid dysfunction, these patients should be referred to medical department for further management.",
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AU - Chang, Julia Yu Fong

AU - Chiang, Chun Pin

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AU - Wu, Yang Che

AU - Chen, Hsin Ming

AU - Sun, Andy

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N2 - Background: Desquamative gingivitis (DG) is principally associated with erosive oral lichen planus (EOLP), mucous membrane pemphigoid (MMP), and pemphigus vulgaris (PV). Methods: Serum autoantibodies including antigastric parietal cell antibody (GPCA), antithyroglobulin antibody (TGA), and antithyroid microsomal antibody (TMA) were measured in 500 patients with DG, 287 EOLP without DG (EOLP/DG − ) patients, and 100 healthy control subjects. Results: The 500 patients with DG were diagnosed as having EOLP in 455 (91%), PV in 40 (8%), and MMP in five (1%) patients. We found that 37.0%, 43.6%, and 42.6% of 500 patients with DG, 39.6%, 46.4%, and 45.1% of 455 EOLP with DG (EOLP/DG) patients, and 18.5%, 27.5%, and 30.3% of 287 EOLP/DG − patients had the presence of GPCA, TGA, and TMA in their sera, respectively. DG, EOLP/DG, and EOLP/DG − patients all had a significantly higher frequency of GPCA, TGA, or TMA positivity than healthy control subjects (all P-values < 0.001). Moreover, 455 EOLP/DG patients had a significantly higher frequency of GPCA, TGA, or TMA positivity than 287 EOLP/DG − patients (all P-values < 0.001). Of 210 TGA/TMA-positive patients with DG whose serum thyroid-stimulating hormone (TSH) levels were measured, 84.3%, 6.7%, and 9.0% patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: We conclude that 73.4% DG, 77.1% EOLP/DG, and 47.4% EOLP/DG − patients may have GPCA/TGA/TMA positivity in their sera. Because part of GPCA-positive patients may develop pernicious anemia, autoimmune atrophic gastritis, and gastric carcinoma, and part of TGA/TMA-positive patients may have thyroid dysfunction, these patients should be referred to medical department for further management.

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