Antidiabetic effects of momordica charantia and psidum guajava extract in type ii diabetes rats

Ying Ying Chaing, Chin Ping Hsu, Ting Yi Chien, Chun Han Tsai, Yu Yo Kao, Huan Chun Chao, Hui Yu Huang

Research output: Contribution to journalArticle

Abstract

Bitter melon and guava leaf are rich in polyphenols which exert beneficial health effects to ameliorate metabolic diseases. In the present study, we examined the effects of bitter melon and guava leaf extract (EBGL) on hyperglycemia in rats given a high-fat diet and with diabetes induced by low-dose streptozotocin. Diabetic rats were then randomly separated into a diabetic group and different EBGL dosage treatment groups (groups A, B, and C at 36.5, 182.3, and 364.6 mg/kg/day, respectively) . The body weight, serum glucose level, insulin level, [glycated hemoglobin (HbA1c) , and Oral Glucose Tolerance Test (OGTT) were measured at optimal time intervals of the experimental duration. Results showed that treatment of diabetic rats with EBGL dramatically reduced the fasting blood glucose and HbA1c, and also improved serum insulin secretion and OGTT relative to the untreated diabetic group (p < 0.05) . Treatment groups showed lower weigh gain compared to the untreated diabetic group. However, chronic treatment of diabetic rats with EBGL could prevent abnormal changes in blood glucose and attenuate the development of diabetes.

Original languageEnglish
Pages (from-to)66-74
Number of pages9
JournalNutritional Sciences Journal
Volume37
Issue number2
Publication statusPublished - Dec 1 2012
Externally publishedYes

Fingerprint

Momordica charantia
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Psidium
Glucose Tolerance Test
Blood Glucose
Insulin
Metabolic Diseases
Glycosylated Hemoglobin A
Polyphenols
High Fat Diet
Streptozocin
Serum
Hyperglycemia
Fasting
Body Weight
Glucose
Health

Keywords

  • Bitter melon
  • Blood glucose
  • Guava leaf
  • Insulin
  • Type II diabetes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Chaing, Y. Y., Hsu, C. P., Chien, T. Y., Tsai, C. H., Kao, Y. Y., Chao, H. C., & Huang, H. Y. (2012). Antidiabetic effects of momordica charantia and psidum guajava extract in type ii diabetes rats. Nutritional Sciences Journal, 37(2), 66-74.

Antidiabetic effects of momordica charantia and psidum guajava extract in type ii diabetes rats. / Chaing, Ying Ying; Hsu, Chin Ping; Chien, Ting Yi; Tsai, Chun Han; Kao, Yu Yo; Chao, Huan Chun; Huang, Hui Yu.

In: Nutritional Sciences Journal, Vol. 37, No. 2, 01.12.2012, p. 66-74.

Research output: Contribution to journalArticle

Chaing, YY, Hsu, CP, Chien, TY, Tsai, CH, Kao, YY, Chao, HC & Huang, HY 2012, 'Antidiabetic effects of momordica charantia and psidum guajava extract in type ii diabetes rats', Nutritional Sciences Journal, vol. 37, no. 2, pp. 66-74.
Chaing YY, Hsu CP, Chien TY, Tsai CH, Kao YY, Chao HC et al. Antidiabetic effects of momordica charantia and psidum guajava extract in type ii diabetes rats. Nutritional Sciences Journal. 2012 Dec 1;37(2):66-74.
Chaing, Ying Ying ; Hsu, Chin Ping ; Chien, Ting Yi ; Tsai, Chun Han ; Kao, Yu Yo ; Chao, Huan Chun ; Huang, Hui Yu. / Antidiabetic effects of momordica charantia and psidum guajava extract in type ii diabetes rats. In: Nutritional Sciences Journal. 2012 ; Vol. 37, No. 2. pp. 66-74.
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