Anticancer Effects of Taiwanofungus camphoratus Extracts, Isolated Compounds and its Combinational use

Ying Chen Chen, Hsio O. Ho, Chin Hua Su, Ming Thau Sheu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Taiwanofungus camphoratus is an indigenous mushroom in Taiwan, which has been used as a traditional medicine to treat many health-related problems. Several biological activities have been reported on T. camphoratus ranging from anti-inflammatory antihypertension to anticancer and so on. Cancer is a major cause of death in Taiwan, and unfortunately, there is no satisfied treatment presently. Thus, a review article about the anticancer effect of T. camphoratus would be a great importance. This article reviews anticancer activities being performed with crude extracts and isolated compounds from T. camphoratus and their synergistic effects. The source of T. camphoratus might be from its fruiting bodies, mycelia, and fermented culture broth and be extracted from water, methanol, ethanol, ethyl acetate, or chloroform, which showed versatile anticancer activities. In addition, various compounds have been further purified from these extracts, such as terpenoids, maleic and succinic acids derivatives, polysaccharides, and other compounds, and they also showed potent cytotoxicity. Besides, T. camphoratus not only has cytotoxic effect but also produces synergistic anticancer effect with trichostatin A, lovastatin, and taxol. It is concluded that T. camphoratus could be considered as a potential anticancer agent to make cancer no longer a frightening nightmare. However, clinical trials of T. camphoratus on human subjects are absent, and the involved mechanism remains unclear. Hence, further investigations would be required.

Original languageEnglish
Pages (from-to)274-281
Number of pages8
JournalJournal of Experimental and Clinical Medicine(Taiwan)
Volume2
Issue number6
DOIs
Publication statusPublished - Dec 2010

Fingerprint

Taiwan
trichostatin A
Succinates
Lovastatin
Agaricales
Mycelium
Terpenes
Traditional Medicine
Chloroform
Paclitaxel
Complex Mixtures
Antineoplastic Agents
Polysaccharides
Methanol
Cause of Death
Neoplasms
Anti-Inflammatory Agents
Ethanol
Clinical Trials
Water

Keywords

  • Anticancer
  • Combination
  • Crude extracts
  • Pure compounds
  • Taiwanofungus camphoratus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Anticancer Effects of Taiwanofungus camphoratus Extracts, Isolated Compounds and its Combinational use. / Chen, Ying Chen; Ho, Hsio O.; Su, Chin Hua; Sheu, Ming Thau.

In: Journal of Experimental and Clinical Medicine(Taiwan), Vol. 2, No. 6, 12.2010, p. 274-281.

Research output: Contribution to journalArticle

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