Anticancer effect of curcumin on breast cancer and stem cells

Hui-Tien Liu, Yuan-Soon Ho

Research output: Contribution to journalReview article

Abstract

Numerous studies have shown that curcumin, a natural compound, exerts anticancer effects by inhibiting cancer cell proliferation and metastasis and by inducing cell cycle arrest and apoptosis. In particular, curcumin exhibits potent inhibitory effects on breast cancer, the most prevalent type of cancer among women worldwide. It has low maximal inhibitory concentration for breast cancer cell lines that express the hormone receptor ER and sensitizes cell lines to anticancer drugs. Moreover, it can induce apoptosis in cell lines independently of hormone receptor expression. In addition, curcumin inhibits the proliferation of breast cancer stem cells (BCSC), an important factor that influences cancer recurrence. The inhibition of BCSC proliferation suppresses metastasis and reattachment, ultimately limiting tumor formation. A xenograft study similarly showed that curcumin exerts tumor-suppression effects on cancer cells and cancer stem cells. Therefore, curcumin is a potential anticancer compound, and its concurrent application with other anticancer drugs appears promising.
Original languageEnglish
Pages (from-to)134-137
JournalFood Science and Human Wellness
Publication statusPublished - Jun 2018

Fingerprint

Curcumin
Neoplastic Stem Cells
Breast Neoplasms
Neoplasms
Cell Line
Cell Proliferation
Hormones
Apoptosis
Neoplasm Metastasis
Stem Cell Factor
Cell Cycle Checkpoints
Heterografts
Pharmaceutical Preparations
Recurrence

Cite this

Anticancer effect of curcumin on breast cancer and stem cells. / Liu, Hui-Tien; Ho, Yuan-Soon.

In: Food Science and Human Wellness, 06.2018, p. 134-137.

Research output: Contribution to journalReview article

@article{b5db1b9a8905490fa7f70d156680459e,
title = "Anticancer effect of curcumin on breast cancer and stem cells",
abstract = "Numerous studies have shown that curcumin, a natural compound, exerts anticancer effects by inhibiting cancer cell proliferation and metastasis and by inducing cell cycle arrest and apoptosis. In particular, curcumin exhibits potent inhibitory effects on breast cancer, the most prevalent type of cancer among women worldwide. It has low maximal inhibitory concentration for breast cancer cell lines that express the hormone receptor ER and sensitizes cell lines to anticancer drugs. Moreover, it can induce apoptosis in cell lines independently of hormone receptor expression. In addition, curcumin inhibits the proliferation of breast cancer stem cells (BCSC), an important factor that influences cancer recurrence. The inhibition of BCSC proliferation suppresses metastasis and reattachment, ultimately limiting tumor formation. A xenograft study similarly showed that curcumin exerts tumor-suppression effects on cancer cells and cancer stem cells. Therefore, curcumin is a potential anticancer compound, and its concurrent application with other anticancer drugs appears promising.",
author = "Hui-Tien Liu and Yuan-Soon Ho",
year = "2018",
month = "6",
language = "English",
pages = "134--137",
journal = "Food Science and Human Wellness",
issn = "2213-4530",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Anticancer effect of curcumin on breast cancer and stem cells

AU - Liu, Hui-Tien

AU - Ho, Yuan-Soon

PY - 2018/6

Y1 - 2018/6

N2 - Numerous studies have shown that curcumin, a natural compound, exerts anticancer effects by inhibiting cancer cell proliferation and metastasis and by inducing cell cycle arrest and apoptosis. In particular, curcumin exhibits potent inhibitory effects on breast cancer, the most prevalent type of cancer among women worldwide. It has low maximal inhibitory concentration for breast cancer cell lines that express the hormone receptor ER and sensitizes cell lines to anticancer drugs. Moreover, it can induce apoptosis in cell lines independently of hormone receptor expression. In addition, curcumin inhibits the proliferation of breast cancer stem cells (BCSC), an important factor that influences cancer recurrence. The inhibition of BCSC proliferation suppresses metastasis and reattachment, ultimately limiting tumor formation. A xenograft study similarly showed that curcumin exerts tumor-suppression effects on cancer cells and cancer stem cells. Therefore, curcumin is a potential anticancer compound, and its concurrent application with other anticancer drugs appears promising.

AB - Numerous studies have shown that curcumin, a natural compound, exerts anticancer effects by inhibiting cancer cell proliferation and metastasis and by inducing cell cycle arrest and apoptosis. In particular, curcumin exhibits potent inhibitory effects on breast cancer, the most prevalent type of cancer among women worldwide. It has low maximal inhibitory concentration for breast cancer cell lines that express the hormone receptor ER and sensitizes cell lines to anticancer drugs. Moreover, it can induce apoptosis in cell lines independently of hormone receptor expression. In addition, curcumin inhibits the proliferation of breast cancer stem cells (BCSC), an important factor that influences cancer recurrence. The inhibition of BCSC proliferation suppresses metastasis and reattachment, ultimately limiting tumor formation. A xenograft study similarly showed that curcumin exerts tumor-suppression effects on cancer cells and cancer stem cells. Therefore, curcumin is a potential anticancer compound, and its concurrent application with other anticancer drugs appears promising.

M3 - Review article

SP - 134

EP - 137

JO - Food Science and Human Wellness

JF - Food Science and Human Wellness

SN - 2213-4530

ER -