Antibody-mediated endothelial cell damage via nitric oxide

Y. S. Lin, C. F. Lin, H. Y. Lei, H. S. Liu, T. M. Yeh, S. H. Chen, C. C. Liu

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Vascular disorders, resulting from endothelial cell dysfunction, may be caused by various stimuli, including infectious, pathogens, cytotoxic reagents, and pathophysiological mechanisms mediated by immune responses. Endothelial cell dysfunction characterized by apoptosis and abnormal immune activation is, at least in part, induced by anti-endothelial cell antibody (AECA) in some cases of autoimmune disease. However, the molecular mechanisms of AECA-mediated pathogenetic damage to host vascular system remain unclear. The dual role of nitric oxide (NO) both in endothelial cell apoptosis and survival has been described. In this paper, endothelial cell apoptosis caused by the presence of cross-reactive AECA via a NO-mediated mechanism is demonstrated in dengue virus infection. Endothelial cells undergo apoptosis via the mitochondria-dependent pathway that is regulated by NO production. NO-regulated endothelial cell injury thus may play a role in the disruption of vessel endothelium and contribute to the AECA-induced pathogenesis of vasculopathy. The modulation of NO may provide the therapeutic strategies for autoimmune diseases by preventing the AECA-mediated endothelial cell damage.

Original languageEnglish
Pages (from-to)213-221
Number of pages9
JournalCurrent Pharmaceutical Design
Volume10
Issue number2
DOIs
Publication statusPublished - 2004
Externally publishedYes

Fingerprint

Nitric Oxide
Endothelial Cells
Antibodies
Apoptosis
Autoimmune Diseases
Blood Vessels
Dengue Virus
Virus Diseases
Endothelium
Cell Survival
Mitochondria
anti-endothelial cell antibody
Wounds and Injuries

Keywords

  • Anti-endothelial cell antibody
  • Apoptosis
  • Nitric oxide

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Lin, Y. S., Lin, C. F., Lei, H. Y., Liu, H. S., Yeh, T. M., Chen, S. H., & Liu, C. C. (2004). Antibody-mediated endothelial cell damage via nitric oxide. Current Pharmaceutical Design, 10(2), 213-221. https://doi.org/10.2174/1381612043453469

Antibody-mediated endothelial cell damage via nitric oxide. / Lin, Y. S.; Lin, C. F.; Lei, H. Y.; Liu, H. S.; Yeh, T. M.; Chen, S. H.; Liu, C. C.

In: Current Pharmaceutical Design, Vol. 10, No. 2, 2004, p. 213-221.

Research output: Contribution to journalArticle

Lin, YS, Lin, CF, Lei, HY, Liu, HS, Yeh, TM, Chen, SH & Liu, CC 2004, 'Antibody-mediated endothelial cell damage via nitric oxide', Current Pharmaceutical Design, vol. 10, no. 2, pp. 213-221. https://doi.org/10.2174/1381612043453469
Lin, Y. S. ; Lin, C. F. ; Lei, H. Y. ; Liu, H. S. ; Yeh, T. M. ; Chen, S. H. ; Liu, C. C. / Antibody-mediated endothelial cell damage via nitric oxide. In: Current Pharmaceutical Design. 2004 ; Vol. 10, No. 2. pp. 213-221.
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