Antibacterial and cytotoxic activities of different wild bitter gourd cultivars (Momordica charantia L. var. abbreviata Seringe)

Yeh Lin Lu, Yuh Hwa Liu, Wen Li Liang, Jong Ho Chuang, Kur Ta Cheng, Hong Jen Liang, Wen Chi Hou

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Wild bitter gourd (Momordica charantia L. var. abbreviata Seringe, MCA), which is normally smaller than cultivated bitter gourd (Momordica charantia L., MC), both belong to the family Cucurbitaceae. The fresh fruits of MC and MCA are frequently used as vegetables in Taiwan. Water (H) and methanolic (M) extracts of sixteen cultivars from Taiwanese indigenous MCA (10 mg/mL) were tested for their antibacterial activities toward the methicillin-resistant Staphylococcus aureus subsp. aureus (ATCC 33591), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 10536), and Salmonella enterica subsp. enterica (ATCC 19126), and for their cytotoxic activities toward human fibrosarcoma HT 1080 cells. None of the extracts showed inhibitory activity against methicillin-resistant Staphylococcus aureus or Pseudomonas aeruginosa, however, several H and M extracts (even H extracts that were heated at 100°C for 5 min) showed inhibitory activity against the growth of Escherichia coli and Salmonella enterica. For cytotoxic activities toward human fibrosarcoma HT 1080 cells, H extracts (1 mg/mL) from mature D, E, and F cultivars, and M extracts (1 mg/mL) from mature D and E cultivars showed similar cytotoxic activities compared to that of 10 μg/mL of doxorubicin. The use of MCA extracts as natural food additives to control food-borne pathogens and/or their development as health foods for chemoprevention in the future is discussed.

Original languageEnglish
Pages (from-to)427-434
Number of pages8
JournalBotanical Studies
Volume52
Issue number4
Publication statusPublished - Oct 2011

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Abbreviata
Momordica charantia
extracts
cultivars
fibrosarcoma
Pseudomonas aeruginosa
Staphylococcus aureus subsp. aureus
Salmonella enterica subsp. enterica
natural additives
Escherichia coli
chemoprevention
doxorubicin
health foods
natural foods
Salmonella enterica
Cucurbitaceae
food additives
food pathogens
raw fruit
Taiwan

Keywords

  • Antibacterial activity
  • Cytotoxic activity
  • Escherichia coli
  • Momordica charantia L. var. abbreviata Seringe (MCA)
  • Salmonella enteric

ASJC Scopus subject areas

  • Plant Science

Cite this

Antibacterial and cytotoxic activities of different wild bitter gourd cultivars (Momordica charantia L. var. abbreviata Seringe). / Lu, Yeh Lin; Liu, Yuh Hwa; Liang, Wen Li; Chuang, Jong Ho; Cheng, Kur Ta; Liang, Hong Jen; Hou, Wen Chi.

In: Botanical Studies, Vol. 52, No. 4, 10.2011, p. 427-434.

Research output: Contribution to journalArticle

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