Antibacterial activity of cefprozil in vitro

Y. C. Liu, W. K. Huang, D. L. Cheng

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cefprozil is a new orally active cephalosporin which is undergoing in vitro and in vivo evaluations. Using the standard agar dilution method we compared the in vitro activity of this drug with other oral cephalosporins and ciprofloxacin against 637 recent clinical isolates from the Kaohsiung Veterans General Hospital, Taiwan. Against Escherichia coli and Klebsiella pneumoniae, cefprozil showed good activity, inhibiting over 80% of these isolates at 8 mg/l. Like other oral drugs of its class, it had little activity against Pseudomonas aeruginosa and Acinetobacter spp. Against Haemophilus influenzae, irrespective of β-lactamase production, its activity was similar to comparable drugs. Against methicillin-susceptible Staphylococcus aureus, cefprozil showed high activity, inhibiting 90% of these isolates at 4 mg/l, whereas against methicillin-resistant S. aureus, its activity was higher than that of other oral cephalosporins tested and was similar to that of ciprofloxacin. Of enterococci tested, 57.7% were inhibited by 8 mg/l of cefprozil. Against β-hemolytic streptococci, its activity was superior to all other drugs tested. The results of this in vitro study indicate that oral administration of cefprozil might be efficacious in the treatment of community-acquired cutaneous, respiratory and urinary tract infections.

Original languageEnglish
Pages (from-to)427-432
Number of pages6
JournalChemotherapy
Volume41
Issue number6
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Cephalosporins
Ciprofloxacin
Pharmaceutical Preparations
Veterans Hospitals
Acinetobacter
Methicillin
Enterococcus
Haemophilus influenzae
Klebsiella pneumoniae
Methicillin-Resistant Staphylococcus aureus
Streptococcus
Taiwan
Urinary Tract Infections
General Hospitals
Respiratory Tract Infections
Pseudomonas aeruginosa
Agar
Oral Administration
Staphylococcus aureus
cefprozil

Keywords

  • Cefprozil
  • Cephalosporin
  • In vitro activity

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Liu, Y. C., Huang, W. K., & Cheng, D. L. (1995). Antibacterial activity of cefprozil in vitro. Chemotherapy, 41(6), 427-432.

Antibacterial activity of cefprozil in vitro. / Liu, Y. C.; Huang, W. K.; Cheng, D. L.

In: Chemotherapy, Vol. 41, No. 6, 1995, p. 427-432.

Research output: Contribution to journalArticle

Liu, YC, Huang, WK & Cheng, DL 1995, 'Antibacterial activity of cefprozil in vitro', Chemotherapy, vol. 41, no. 6, pp. 427-432.
Liu YC, Huang WK, Cheng DL. Antibacterial activity of cefprozil in vitro. Chemotherapy. 1995;41(6):427-432.
Liu, Y. C. ; Huang, W. K. ; Cheng, D. L. / Antibacterial activity of cefprozil in vitro. In: Chemotherapy. 1995 ; Vol. 41, No. 6. pp. 427-432.
@article{f49574c9e58048108c6c15f938b8ea72,
title = "Antibacterial activity of cefprozil in vitro",
abstract = "Cefprozil is a new orally active cephalosporin which is undergoing in vitro and in vivo evaluations. Using the standard agar dilution method we compared the in vitro activity of this drug with other oral cephalosporins and ciprofloxacin against 637 recent clinical isolates from the Kaohsiung Veterans General Hospital, Taiwan. Against Escherichia coli and Klebsiella pneumoniae, cefprozil showed good activity, inhibiting over 80{\%} of these isolates at 8 mg/l. Like other oral drugs of its class, it had little activity against Pseudomonas aeruginosa and Acinetobacter spp. Against Haemophilus influenzae, irrespective of β-lactamase production, its activity was similar to comparable drugs. Against methicillin-susceptible Staphylococcus aureus, cefprozil showed high activity, inhibiting 90{\%} of these isolates at 4 mg/l, whereas against methicillin-resistant S. aureus, its activity was higher than that of other oral cephalosporins tested and was similar to that of ciprofloxacin. Of enterococci tested, 57.7{\%} were inhibited by 8 mg/l of cefprozil. Against β-hemolytic streptococci, its activity was superior to all other drugs tested. The results of this in vitro study indicate that oral administration of cefprozil might be efficacious in the treatment of community-acquired cutaneous, respiratory and urinary tract infections.",
keywords = "Cefprozil, Cephalosporin, In vitro activity",
author = "Liu, {Y. C.} and Huang, {W. K.} and Cheng, {D. L.}",
year = "1995",
language = "English",
volume = "41",
pages = "427--432",
journal = "Chemotherapy",
issn = "0009-3157",
publisher = "S. Karger AG",
number = "6",

}

TY - JOUR

T1 - Antibacterial activity of cefprozil in vitro

AU - Liu, Y. C.

AU - Huang, W. K.

AU - Cheng, D. L.

PY - 1995

Y1 - 1995

N2 - Cefprozil is a new orally active cephalosporin which is undergoing in vitro and in vivo evaluations. Using the standard agar dilution method we compared the in vitro activity of this drug with other oral cephalosporins and ciprofloxacin against 637 recent clinical isolates from the Kaohsiung Veterans General Hospital, Taiwan. Against Escherichia coli and Klebsiella pneumoniae, cefprozil showed good activity, inhibiting over 80% of these isolates at 8 mg/l. Like other oral drugs of its class, it had little activity against Pseudomonas aeruginosa and Acinetobacter spp. Against Haemophilus influenzae, irrespective of β-lactamase production, its activity was similar to comparable drugs. Against methicillin-susceptible Staphylococcus aureus, cefprozil showed high activity, inhibiting 90% of these isolates at 4 mg/l, whereas against methicillin-resistant S. aureus, its activity was higher than that of other oral cephalosporins tested and was similar to that of ciprofloxacin. Of enterococci tested, 57.7% were inhibited by 8 mg/l of cefprozil. Against β-hemolytic streptococci, its activity was superior to all other drugs tested. The results of this in vitro study indicate that oral administration of cefprozil might be efficacious in the treatment of community-acquired cutaneous, respiratory and urinary tract infections.

AB - Cefprozil is a new orally active cephalosporin which is undergoing in vitro and in vivo evaluations. Using the standard agar dilution method we compared the in vitro activity of this drug with other oral cephalosporins and ciprofloxacin against 637 recent clinical isolates from the Kaohsiung Veterans General Hospital, Taiwan. Against Escherichia coli and Klebsiella pneumoniae, cefprozil showed good activity, inhibiting over 80% of these isolates at 8 mg/l. Like other oral drugs of its class, it had little activity against Pseudomonas aeruginosa and Acinetobacter spp. Against Haemophilus influenzae, irrespective of β-lactamase production, its activity was similar to comparable drugs. Against methicillin-susceptible Staphylococcus aureus, cefprozil showed high activity, inhibiting 90% of these isolates at 4 mg/l, whereas against methicillin-resistant S. aureus, its activity was higher than that of other oral cephalosporins tested and was similar to that of ciprofloxacin. Of enterococci tested, 57.7% were inhibited by 8 mg/l of cefprozil. Against β-hemolytic streptococci, its activity was superior to all other drugs tested. The results of this in vitro study indicate that oral administration of cefprozil might be efficacious in the treatment of community-acquired cutaneous, respiratory and urinary tract infections.

KW - Cefprozil

KW - Cephalosporin

KW - In vitro activity

UR - http://www.scopus.com/inward/record.url?scp=0028818734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028818734&partnerID=8YFLogxK

M3 - Article

VL - 41

SP - 427

EP - 432

JO - Chemotherapy

JF - Chemotherapy

SN - 0009-3157

IS - 6

ER -