Antiangiogenic activities of polysaccharides isolated from medicinal fungi

Shih-Chung Chen, Mei Kuang Lu, Jing Jy Cheng, Ling Wang Danny

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Extracted polysaccharides from medicinal fungi, including Antrodia cinnamomea, Antrodia malicola, Antrodia xantha, Antrodiella liebmannii, Agaricus murrill, and Rigidoporus ulmarius, were investigated for their effects on vascular endothelial growth factor (VEGF)-induced tube formation in endothelial cells (ECs). Chemical analysis revealed that myo-inositol, sorbitol, fucose, galactosamine, glucosamine, galactose, glucose, and mannose were the neutral sugars in these polysaccharides. These fungal polysaccharides showed no toxicity to ECs. For the inhibition of endothelial tube formation, extracted polysaccharides from A. xantha and R. ulmarius were shown to produce greater inhibition compared to those from other fungi. Fucose, glucose and mannose were the predominant monosaccharides from these two fungi. These results suggest that monosaccharides may play a role in the inhibitory effect of these fungi on endothelial tube formation. In contrast to the inhibition on tube formation from polysaccharides of A. cinnamomea and A. malicola, polysaccharides from A. xantha and R. ulmarius, with molecular weight between 2693-2876 and 304-325 kDa, were critical for this inhibitory activity. Our results show that polysaccharides isolated from A. xantha and R. ulmarius provide greater antiangiogenesis than those from commercialized A. murrill (Brazilian mushroom) and A. cinnamomea. These studies provide a basis for the potential development of these polysaccharides for antiangiogenesis usage.

Original languageEnglish
Pages (from-to)247-254
Number of pages8
JournalFEMS Microbiology Letters
Volume249
Issue number2
DOIs
Publication statusPublished - Aug 15 2005

Fingerprint

Polysaccharides
Fungi
Antrodia
Fucose
Monosaccharides
Mannose
Fungal Polysaccharides
Endothelial Cells
Agaricus
Glucose
Galactosamine
Sorbitol
Agaricales
Glucosamine
Inositol
Galactose
Vascular Endothelial Growth Factor A
Molecular Weight

Keywords

  • Angiogenesis
  • Endothelial cell
  • Fungi
  • Polysaccharides
  • VEGF

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Antiangiogenic activities of polysaccharides isolated from medicinal fungi. / Chen, Shih-Chung; Lu, Mei Kuang; Cheng, Jing Jy; Danny, Ling Wang.

In: FEMS Microbiology Letters, Vol. 249, No. 2, 15.08.2005, p. 247-254.

Research output: Contribution to journalArticle

Chen, Shih-Chung ; Lu, Mei Kuang ; Cheng, Jing Jy ; Danny, Ling Wang. / Antiangiogenic activities of polysaccharides isolated from medicinal fungi. In: FEMS Microbiology Letters. 2005 ; Vol. 249, No. 2. pp. 247-254.
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