Anti-platelet and anti-endothelial cell autoantibodies in Vietnamese infants and children with dengue hemorrhagic fever

Nguyen Thanh Hung, Nguyen Trong Lan, Yee Shin Lin, Chiou Feng Lin, Le Bich Lien, Kao Jean Huang, Trai Ming Yeh, Do Quang Ha, Vu Thi Que Huong, Lien Cheng Chen, Lam Thi My, Jyh Hsiung Huang, Ching Chuan Liu, Huan Yao Lei

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Dengue hemorrhagic fever (DHF) is a serious public health problem. Increased vascular permeability and thrombocytopenia are the hallmarks of DHF. The mechanisms involved in DHF/Dengue shock syndrome (DSS) pathogenesis is not fully understood. This study gives evidence of the presence of antibodies which cross-reacted with platelets, and endothelial cells in the sera of Vietnamese infants and children with DHF/DSS. The anti-platelet, anti-endothelial cell IgM levels were higher in the sera of DHF/DSS infants and children, compared with controls. However, the levels of these autoantibodies were not correlated with the severity of DHF (non-shock DHF vs DSS). The anti-platelet, and anti-endothelial cell autoantibodies may play a role in the pathogenesis of DHF/DSS in infants and children with predominantly primary, and secondary dengue infections, respectively. The epitopes shared by surface molecules of platelets and endothelial cells and dengue virus antigens need to be identified and avoided in designing the safe candidate vaccines.

Original languageEnglish
Pages (from-to)41-49
Number of pages9
JournalAmerican Journal of Infectious Diseases
Volume4
Issue number1
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Severe Dengue
Autoantibodies
Blood Platelets
Endothelial Cells
Dengue Virus
Dengue

Keywords

  • Autoantibody
  • Children
  • Dengue hemorrhagic fever
  • Endothelial cells
  • Infants
  • Platelets

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Anti-platelet and anti-endothelial cell autoantibodies in Vietnamese infants and children with dengue hemorrhagic fever. / Hung, Nguyen Thanh; Lan, Nguyen Trong; Lin, Yee Shin; Lin, Chiou Feng; Lien, Le Bich; Huang, Kao Jean; Yeh, Trai Ming; Ha, Do Quang; Huong, Vu Thi Que; Chen, Lien Cheng; My, Lam Thi; Huang, Jyh Hsiung; Liu, Ching Chuan; Lei, Huan Yao.

In: American Journal of Infectious Diseases, Vol. 4, No. 1, 2008, p. 41-49.

Research output: Contribution to journalArticle

Hung, NT, Lan, NT, Lin, YS, Lin, CF, Lien, LB, Huang, KJ, Yeh, TM, Ha, DQ, Huong, VTQ, Chen, LC, My, LT, Huang, JH, Liu, CC & Lei, HY 2008, 'Anti-platelet and anti-endothelial cell autoantibodies in Vietnamese infants and children with dengue hemorrhagic fever', American Journal of Infectious Diseases, vol. 4, no. 1, pp. 41-49.
Hung, Nguyen Thanh ; Lan, Nguyen Trong ; Lin, Yee Shin ; Lin, Chiou Feng ; Lien, Le Bich ; Huang, Kao Jean ; Yeh, Trai Ming ; Ha, Do Quang ; Huong, Vu Thi Que ; Chen, Lien Cheng ; My, Lam Thi ; Huang, Jyh Hsiung ; Liu, Ching Chuan ; Lei, Huan Yao. / Anti-platelet and anti-endothelial cell autoantibodies in Vietnamese infants and children with dengue hemorrhagic fever. In: American Journal of Infectious Diseases. 2008 ; Vol. 4, No. 1. pp. 41-49.
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