Anti-inflammatory effects of resveratrol and oligostilbenes from vitis thunbergii var. taiwaniana against lipopolysaccharide-induced arthritis

Kun Teng Wang, Lih Geeng Chen, Sung Hui Tseng, Jung Shan Huang, Ming-Shium Hsieh, Ching Chiung Wang

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Vitis thunbergii Sieb. and Zucc. var. taiwaniana Lu is an endemic plant in Taiwan used as a dietary supplement for bone health. In this study, human chondrocytes were induced to produce COX-2, MMP-3, -13, and PGE2 by LPS. An 18F-FDG microPET imaging system was used to evaluate the anti-inflammatory arthritic effects in vivo. Six stilbenes, resveratrol (1), (+)-μ-viniferin (2), ampelopsin C (3), ampelopsin A (4), (-)-vitisin B (5), and (+)-vitisin A (6), were isolated from the stem part of V. thunbergii, which displayed the strongest PGE2 inhibition. Among these compounds, 1 significantly decreased COX-2 activity, PGE2, MMP-3, and -13 production in vitro, and 18F-FDG uptake and serum PGE2 in rabbits in vivo. Anti-inflammatory effects were enhanced through the combined usage of 1 and other oligostilbenes. Taken together, the synergistic effects of 1 and oligostilbenes resulted in stem part extracts with lower 1 content displaying the better anti-inflammatory arthritis effects.

Original languageEnglish
Pages (from-to)3649-3656
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Volume59
Issue number8
DOIs
Publication statusPublished - Apr 27 2011

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Keywords

  • F-FDG microPET
  • inflammatory arthritis
  • oligostilbenes
  • resveratrol
  • synergistic effects
  • Vitis thunbergii var. taiwaniana

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

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