Anti-inflammatory Effect of the 5,7,4′-Trihydroxy-6-geranylflavanone isolated from the fruit of artocarpus communis in S100b-induced human monocytes

Jer An Lin, Song Chwan Fang, Chi Hao Wu, Shang Ming Huang, Gow Chin Yen

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The fruit of Artocarpus communis Moraceae, a traditional starch crop, is a rich source of phytochemicals, such as flavonoids and their derivatives. The aim of this study was to investigate whether 5,7,4′-trihydroxy-6- geranylflavanone (AC-GF), a geranyl flavonoid derivative isolated from the fruits of A. communis, could decrease the activation of inflammatory mediators induced by S100B (ligand of receptor for advanced glycation end products, RAGE) in THP-1 monocytes. According to the results, low levels of AC-GF (≤2.5 μM) showed a great inhibitory effect on gene expression of RAGE and down-regulated both TNF-α and IL-1β secretion and gene expression (p <0.05). AC-GF also decreased reactive oxygen species (ROS) production in response to S100B (p <0.05). Additionally, Western blotting revealed that AC-GF could effectively attenuate RAGE-dependent signaling, including expression of protein kinase C (PKC) and p47phox, phosphorylation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK), and particularly NF-κB activation (p <0.05). In conclusion, this is the first report that AC-GF possesses great antioxidant and anti-inflammatory properties in vitro. This finding may contribute to increased implication and utilization of the fruit of A. communis Moraceae in functional foods.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume59
Issue number1
DOIs
Publication statusPublished - Jan 12 2011
Externally publishedYes

Keywords

  • 5,7,4′-Trihydroxy-6-geranylflavanone
  • Artocarpus communis Moraceae
  • RAGE
  • S100B
  • THP-1

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Anti-inflammatory Effect of the 5,7,4′-Trihydroxy-6-geranylflavanone isolated from the fruit of artocarpus communis in S100b-induced human monocytes'. Together they form a unique fingerprint.

  • Cite this