Anti-inflammatory cembranoids from the soft coral lobophytum crassum

Kuei Hung Lai, Wan Jing You, Chi Chen Lin, Mohamed El-Shazly, Zuo Jian Liao, Jui Hsin Su

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Cembrane-type diterpenoids are among the most frequently encountered natural products from the soft corals of the genus Lobophytum. In the course of our investigation to identify anti-inflammatory constituents from a wild-type soft coral Lobophytum crassum, two new cembranoids, lobophyolide A (1) and B (2), along with five known compounds (3–7), were isolated. The structures of these natural products were identified using NMR and MS spectroscopic analyses. Compound 1 was found to possess the first identified α-epoxylactone group among all cembrane-type diterpenoids. The in vitro anti-inflammatory effect of compounds 1–5 was evaluated. The results showed that compounds 1–5 not only reduced IL-12 release, but also attenuated NO production in LPS-activated dendritic cells. Our data indicated that the isolated series of cembrane-type diterpenoids demonstrated interesting structural features and anti-inflammatory activity which could be further developed into therapeutic entities.

Original languageEnglish
Article number327
JournalMarine Drugs
Volume15
Issue number10
DOIs
Publication statusPublished - Oct 2017
Externally publishedYes

Keywords

  • Cembranoids
  • IL-12 production
  • Lobophyolides
  • NO release
  • α-epoxylactone group

ASJC Scopus subject areas

  • Drug Discovery

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  • Cite this

    Lai, K. H., You, W. J., Lin, C. C., El-Shazly, M., Liao, Z. J., & Su, J. H. (2017). Anti-inflammatory cembranoids from the soft coral lobophytum crassum. Marine Drugs, 15(10), [327]. https://doi.org/10.3390/md15100327