Anti-inflammatory, antioxidant, and microbiota-modulating effects of camellia oil from Camellia brevistyla on acetic acid-induced colitis in rats

Chun Ching Wu, Yu Tang Tung, Sheng Yi Chen, Wei Ting Lee, Hsin Tang Lin, Gow Chin Yen

Research output: Contribution to journalArticle

Abstract

Altering the microbiota by the daily diet is highly associated with improved human health. Studies confirms the gastrointestinal protective and anti-inflammatory effects of camellia oil; however, the benefits in gut microbiota remain unclear. Camellia oils of Camellia oleifera (PCO) and C. brevistyla (TCCO) were used to evaluate probiotic growth in vitro. In addition, the protective effects of camellia oils in the acetic acid (AA)-induced colitis rat model were investigated. In vitro fermentation study showed the proliferation of Lactobacillus spp. and Bifidobacterium spp. from human intestinal microbiota was increased after TCCO treatment. Moreover, the rats pretreated with TCCO exhibited significantly less AA-induced colonic injury and hemorrhage, higher serum immunoglobulin G 1 (IgG 1) levels, lower malondialdehyde levels, and lower inflammatory cytokine production in the colon tissue compared with those in the PCO group. Surprising, the protective effect against acetic acid-induced colitis by TCCO was similar to sulfasalazine (positive control) treatment. Moreover, TCCO increased the richness and diversity of probiotics in gut microbiota. TCCO alleviated AA-induced colitis by modulating gut microbiota, reducing oxidative stress and suppressing inflammatory responses.

Original languageEnglish
Article number58
JournalAntioxidants
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 2020

Keywords

  • Anti-inflammation
  • Antioxidant
  • Camellia brevistyla
  • Camellia oil
  • Colitis
  • Gut microbiota

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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