Anti-inflammatory activity of mangostins from Garcinia mangostana

Lih Geeng Chen, Ling-Ling Yang, Ching Chiung Wang

Research output: Contribution to journalArticle

261 Citations (Scopus)

Abstract

The fruit hull of Garcinia mangostana Linn (Guttiferae) is used as an anti-inflammatory drug in Southeast Asia. Two xanthones, α- and γ-mangostins, were isolated from the fruit hull of G. mangostana, and both significantly inhibited nitric oxide (NO) and PGE2 production from lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The IC50 values for the inhibition of NO production by α- and γ-mangostins were 12.4 and 10.1 μM, respectively. After iNOS enzyme activity was stimulated by LPS for 12 h, treatment with either α- or γ-mangostin at 5 μg/ml (12.2 and 12.6 μM, respectively) for 24 h did not significantly inhibit NO production. The data show that the inhibitory activities of α- and γ-mangostins are not due to direct inhibition of iNOS enzyme activity. On the other hand, expression of iNOS was inhibited by α- and γ-mangostins in LPS-stimulated RAW 264.7 cells, but not by COX-2. However, the level of PGE2 production was reduced by the two xanthones. In an in vivo study, α-mangostin significantly inhibited mice carrageenan-induced paw edema. In conclusion, α- and γ-mangostins from G. mangostana are bioactive substances with anti-inflammatory effects.

Original languageEnglish
Pages (from-to)688-693
Number of pages6
JournalFood and Chemical Toxicology
Volume46
Issue number2
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Garcinia mangostana
Garcinia
anti-inflammatory activity
lipopolysaccharides
nitric oxide
xanthones
Anti-Inflammatory Agents
hulls
enzyme activity
Clusiaceae
anti-inflammatory agents
Xanthones
fruits
Lipopolysaccharides
carrageenan
prostaglandin synthase
Nitric Oxide
in vivo studies
South East Asia
edema

Keywords

  • α- and γ-mangostins
  • COX-2
  • Garcinia mangostana Linn
  • Guttiferae
  • Inducible nitric oxide synthase
  • RAW 264.7 murine macrophages

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Anti-inflammatory activity of mangostins from Garcinia mangostana. / Chen, Lih Geeng; Yang, Ling-Ling; Wang, Ching Chiung.

In: Food and Chemical Toxicology, Vol. 46, No. 2, 02.2008, p. 688-693.

Research output: Contribution to journalArticle

Chen, Lih Geeng ; Yang, Ling-Ling ; Wang, Ching Chiung. / Anti-inflammatory activity of mangostins from Garcinia mangostana. In: Food and Chemical Toxicology. 2008 ; Vol. 46, No. 2. pp. 688-693.
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