Anti-inflammatory activities of tormentic acid from suspension cells of Eriobotrya Japonica ex vivo and in vivo

Chwen Tzuei Chang, Shyh Shyun Huang, Shiang Shiou Lin, Sakae Amagaya, Hui Ya Ho, Wen Chi Hou, Pei Hsin Shie, Jin Bin Wu, Guan Jhong Huang

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Anti-inflammatory effects of tormentic acid (TA) were investigated ex vivo and in vivo. TA decreased the paw edema at the 4th and 5th hour after λ-carrageenin (Carr) administration, and increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the liver tissue. TA also significantly attenuated the thiobarbituric acid reactive substances (TBARS) level in the edematous paw at the 5th hour after Carr injection. TA decreased the nitric oxide (NO) levels on the serum level and diminished the serum tumour necrosis factor (TNF-α) at the 5th hour after Carr injection. Western blotting revealed that the TA decreased Carr-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions. As per results, the anti-inflammatory mechanisms of TA might be correlated to the decrease in the level of TBARS, iNOS, and COX-2 in the edema paw via increasing the activities of CAT, SOD, and GPx in the liver.

Original languageEnglish
Pages (from-to)1131-1137
Number of pages7
JournalFood Chemistry
Volume127
Issue number3
DOIs
Publication statusPublished - Aug 1 2011

Keywords

  • Anti-inflammation
  • NO
  • TBARS
  • TNF-α
  • Tormentic acid

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry

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