Anti-Helicobacter pylori therapy significantly reduces Helicobacter pylori-induced gastric mucosal damage in Mongolian gerbils

Chun Chao Chang, Sheng-Hsuan Chen, Gi Shih Lien, Yuarn Jang Lee, Horng Yuan Lou, Ching Ruey Hsieh, Chia Lang Fang, Shiann Pan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim: To investigate the effectiveness of 4 d' anti-Helicobacter pyloritherapy on the H pylori-infected Mongolian gerbils based on physiological and pathological changes. Methods: We used 6-wk-old male gerbils orally inoculated with H pylori (ATCC43504, 2×108 CFU/mL). Seven weeks after H pylori inoculation, the animals of study group received 4 d' anti-H pyloritriple therapy (H pylori-eradicated group). Seven days later, all animals of the H pylori-eradicated and control groups ( H pylori-infected & H pylori-uninfected groups) were sacrificed. We examined gastric mucosal lesions macroscopically, studied gastritis microscopically and determined the stomach weight ratio, myeloperoxidase (MPO) activity and prostaglandin (PG) E2 level. Results: The results showed that both macroscopic and histological gastric damages were significantly less in H pylori-eradicated group than H pylori-infected group. Stomach weight ratio, MPO activity and PGE2 levels were significantly higher in H pylori-infected group than those in the other two groups. Conclusion: Four days' anti-H pylori therapy was effective in the improvement of H pylori-induced gastric lesions in Mongolian gerbils.

Original languageEnglish
Pages (from-to)982-985
Number of pages4
JournalWorld Journal of Gastroenterology
Volume11
Issue number7
Publication statusPublished - Feb 21 2005

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Gerbillinae
Pylorus
Helicobacter pylori
Stomach
Therapeutics
Dinoprostone
Peroxidase
Helicobacter
Weights and Measures
Gastritis

Keywords

  • Anti-H pylori therapy
  • Gastritis
  • Helicobacter pylori
  • Mongolian gerbils

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Anti-Helicobacter pylori therapy significantly reduces Helicobacter pylori-induced gastric mucosal damage in Mongolian gerbils. / Chang, Chun Chao; Chen, Sheng-Hsuan; Lien, Gi Shih; Lee, Yuarn Jang; Lou, Horng Yuan; Hsieh, Ching Ruey; Fang, Chia Lang; Pan, Shiann.

In: World Journal of Gastroenterology, Vol. 11, No. 7, 21.02.2005, p. 982-985.

Research output: Contribution to journalArticle

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AU - Lou, Horng Yuan

AU - Hsieh, Ching Ruey

AU - Fang, Chia Lang

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