Anti-Helicobacter pylori therapy significantly reduces Helicobacter pylori-induced gastric mucosal damage in Mongolian gerbils

Chun Chao Chang, Sheng-Hsuan Chen, Gi Shih Lien, Yuarn Jang Lee, Horng Yuan Lou, Ching Ruey Hsieh, Chia Lang Fang, Shiann Pan

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3 Citations (Scopus)

Abstract

Aim: To investigate the effectiveness of 4 d' anti-Helicobacter pyloritherapy on the H pylori-infected Mongolian gerbils based on physiological and pathological changes. Methods: We used 6-wk-old male gerbils orally inoculated with H pylori (ATCC43504, 2×108 CFU/mL). Seven weeks after H pylori inoculation, the animals of study group received 4 d' anti-H pyloritriple therapy (H pylori-eradicated group). Seven days later, all animals of the H pylori-eradicated and control groups ( H pylori-infected & H pylori-uninfected groups) were sacrificed. We examined gastric mucosal lesions macroscopically, studied gastritis microscopically and determined the stomach weight ratio, myeloperoxidase (MPO) activity and prostaglandin (PG) E2 level. Results: The results showed that both macroscopic and histological gastric damages were significantly less in H pylori-eradicated group than H pylori-infected group. Stomach weight ratio, MPO activity and PGE2 levels were significantly higher in H pylori-infected group than those in the other two groups. Conclusion: Four days' anti-H pylori therapy was effective in the improvement of H pylori-induced gastric lesions in Mongolian gerbils.

Original languageEnglish
Pages (from-to)982-985
Number of pages4
JournalWorld Journal of Gastroenterology
Volume11
Issue number7
Publication statusPublished - Feb 21 2005

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Keywords

  • Anti-H pylori therapy
  • Gastritis
  • Helicobacter pylori
  • Mongolian gerbils

ASJC Scopus subject areas

  • Gastroenterology

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