Antcamphins A-L, ergostanoids from antrodia camphorata

Yun Huang, Xionghao Lin, Xue Qiao, Shuai Ji, Kedi Liu, Chi Tai Yeh, Yew Min Tzeng, Dean Guo, Min Ye

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Twelve ergostanoids, named antcamphins A-L (1-12), together with 20 known triterpenoids, were isolated from fruiting bodies of the medicinal fungus Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes isolated from A. camphorata, and compounds 3 and 4 are the first pair of cis-trans isomers of ergostane-type triterpenoids containing an aldehyde group. Compounds 5-12 are four pairs of C-25 epimers. The structures of 1-12 were elucidated on the basis of extensive spectroscopic data analysis including NMR and HRESIMS. Particularly, the absolute configurations at C-25 for 5-12 were determined by the modified Mosher's method. These triterpenoids exhibited weak cytotoxic activities against MDA-MB-231 breast cancer cells and A549 lung cancer cells, but did not inhibit the growth of normal cells in the sulforhodamine B assay.

Original languageEnglish
Pages (from-to)118-124
Number of pages7
JournalJournal of Natural Products
Volume77
Issue number1
DOIs
Publication statusPublished - Jan 24 2014

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

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