Antcamphins A-L, ergostanoids from antrodia camphorata

Yun Huang, Xionghao Lin, Xue Qiao, Shuai Ji, Kedi Liu, Chi Tai Yeh, Yew Min Tzeng, Dean Guo, Min Ye

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Twelve ergostanoids, named antcamphins A-L (1-12), together with 20 known triterpenoids, were isolated from fruiting bodies of the medicinal fungus Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes isolated from A. camphorata, and compounds 3 and 4 are the first pair of cis-trans isomers of ergostane-type triterpenoids containing an aldehyde group. Compounds 5-12 are four pairs of C-25 epimers. The structures of 1-12 were elucidated on the basis of extensive spectroscopic data analysis including NMR and HRESIMS. Particularly, the absolute configurations at C-25 for 5-12 were determined by the modified Mosher's method. These triterpenoids exhibited weak cytotoxic activities against MDA-MB-231 breast cancer cells and A549 lung cancer cells, but did not inhibit the growth of normal cells in the sulforhodamine B assay.

Original languageEnglish
Pages (from-to)118-124
Number of pages7
JournalJournal of Natural Products
Volume77
Issue number1
DOIs
Publication statusPublished - Jan 24 2014

Fingerprint

Antrodia
lissamine rhodamine B
Cells
Aldehydes
Lung Neoplasms
Fungi
Breast Neoplasms
Isomers
Assays
Growth
Nuclear magnetic resonance

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Huang, Y., Lin, X., Qiao, X., Ji, S., Liu, K., Yeh, C. T., ... Ye, M. (2014). Antcamphins A-L, ergostanoids from antrodia camphorata. Journal of Natural Products, 77(1), 118-124. https://doi.org/10.1021/np400741s

Antcamphins A-L, ergostanoids from antrodia camphorata. / Huang, Yun; Lin, Xionghao; Qiao, Xue; Ji, Shuai; Liu, Kedi; Yeh, Chi Tai; Tzeng, Yew Min; Guo, Dean; Ye, Min.

In: Journal of Natural Products, Vol. 77, No. 1, 24.01.2014, p. 118-124.

Research output: Contribution to journalArticle

Huang, Y, Lin, X, Qiao, X, Ji, S, Liu, K, Yeh, CT, Tzeng, YM, Guo, D & Ye, M 2014, 'Antcamphins A-L, ergostanoids from antrodia camphorata', Journal of Natural Products, vol. 77, no. 1, pp. 118-124. https://doi.org/10.1021/np400741s
Huang, Yun ; Lin, Xionghao ; Qiao, Xue ; Ji, Shuai ; Liu, Kedi ; Yeh, Chi Tai ; Tzeng, Yew Min ; Guo, Dean ; Ye, Min. / Antcamphins A-L, ergostanoids from antrodia camphorata. In: Journal of Natural Products. 2014 ; Vol. 77, No. 1. pp. 118-124.
@article{c9cea6d76e5f48e3987abb146bdfcb56,
title = "Antcamphins A-L, ergostanoids from antrodia camphorata",
abstract = "Twelve ergostanoids, named antcamphins A-L (1-12), together with 20 known triterpenoids, were isolated from fruiting bodies of the medicinal fungus Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes isolated from A. camphorata, and compounds 3 and 4 are the first pair of cis-trans isomers of ergostane-type triterpenoids containing an aldehyde group. Compounds 5-12 are four pairs of C-25 epimers. The structures of 1-12 were elucidated on the basis of extensive spectroscopic data analysis including NMR and HRESIMS. Particularly, the absolute configurations at C-25 for 5-12 were determined by the modified Mosher's method. These triterpenoids exhibited weak cytotoxic activities against MDA-MB-231 breast cancer cells and A549 lung cancer cells, but did not inhibit the growth of normal cells in the sulforhodamine B assay.",
author = "Yun Huang and Xionghao Lin and Xue Qiao and Shuai Ji and Kedi Liu and Yeh, {Chi Tai} and Tzeng, {Yew Min} and Dean Guo and Min Ye",
year = "2014",
month = "1",
day = "24",
doi = "10.1021/np400741s",
language = "English",
volume = "77",
pages = "118--124",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "1",

}

TY - JOUR

T1 - Antcamphins A-L, ergostanoids from antrodia camphorata

AU - Huang, Yun

AU - Lin, Xionghao

AU - Qiao, Xue

AU - Ji, Shuai

AU - Liu, Kedi

AU - Yeh, Chi Tai

AU - Tzeng, Yew Min

AU - Guo, Dean

AU - Ye, Min

PY - 2014/1/24

Y1 - 2014/1/24

N2 - Twelve ergostanoids, named antcamphins A-L (1-12), together with 20 known triterpenoids, were isolated from fruiting bodies of the medicinal fungus Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes isolated from A. camphorata, and compounds 3 and 4 are the first pair of cis-trans isomers of ergostane-type triterpenoids containing an aldehyde group. Compounds 5-12 are four pairs of C-25 epimers. The structures of 1-12 were elucidated on the basis of extensive spectroscopic data analysis including NMR and HRESIMS. Particularly, the absolute configurations at C-25 for 5-12 were determined by the modified Mosher's method. These triterpenoids exhibited weak cytotoxic activities against MDA-MB-231 breast cancer cells and A549 lung cancer cells, but did not inhibit the growth of normal cells in the sulforhodamine B assay.

AB - Twelve ergostanoids, named antcamphins A-L (1-12), together with 20 known triterpenoids, were isolated from fruiting bodies of the medicinal fungus Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes isolated from A. camphorata, and compounds 3 and 4 are the first pair of cis-trans isomers of ergostane-type triterpenoids containing an aldehyde group. Compounds 5-12 are four pairs of C-25 epimers. The structures of 1-12 were elucidated on the basis of extensive spectroscopic data analysis including NMR and HRESIMS. Particularly, the absolute configurations at C-25 for 5-12 were determined by the modified Mosher's method. These triterpenoids exhibited weak cytotoxic activities against MDA-MB-231 breast cancer cells and A549 lung cancer cells, but did not inhibit the growth of normal cells in the sulforhodamine B assay.

UR - http://www.scopus.com/inward/record.url?scp=84893148885&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893148885&partnerID=8YFLogxK

U2 - 10.1021/np400741s

DO - 10.1021/np400741s

M3 - Article

VL - 77

SP - 118

EP - 124

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 1

ER -