Abstract
Twelve ergostanoids, named antcamphins A-L (1-12), together with 20 known triterpenoids, were isolated from fruiting bodies of the medicinal fungus Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes isolated from A. camphorata, and compounds 3 and 4 are the first pair of cis-trans isomers of ergostane-type triterpenoids containing an aldehyde group. Compounds 5-12 are four pairs of C-25 epimers. The structures of 1-12 were elucidated on the basis of extensive spectroscopic data analysis including NMR and HRESIMS. Particularly, the absolute configurations at C-25 for 5-12 were determined by the modified Mosher's method. These triterpenoids exhibited weak cytotoxic activities against MDA-MB-231 breast cancer cells and A549 lung cancer cells, but did not inhibit the growth of normal cells in the sulforhodamine B assay.
| Original language | English |
|---|---|
| Pages (from-to) | 118-124 |
| Number of pages | 7 |
| Journal | Journal of Natural Products |
| Volume | 77 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 24 2014 |
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ASJC Scopus subject areas
- Complementary and alternative medicine
- Molecular Medicine
- Organic Chemistry
- Analytical Chemistry
- Pharmaceutical Science
- Pharmacology
- Drug Discovery
Cite this
Antcamphins A-L, ergostanoids from antrodia camphorata. / Huang, Yun; Lin, Xionghao; Qiao, Xue; Ji, Shuai; Liu, Kedi; Yeh, Chi Tai; Tzeng, Yew Min; Guo, Dean; Ye, Min.
In: Journal of Natural Products, Vol. 77, No. 1, 24.01.2014, p. 118-124.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antcamphins A-L, ergostanoids from antrodia camphorata
AU - Huang, Yun
AU - Lin, Xionghao
AU - Qiao, Xue
AU - Ji, Shuai
AU - Liu, Kedi
AU - Yeh, Chi Tai
AU - Tzeng, Yew Min
AU - Guo, Dean
AU - Ye, Min
PY - 2014/1/24
Y1 - 2014/1/24
N2 - Twelve ergostanoids, named antcamphins A-L (1-12), together with 20 known triterpenoids, were isolated from fruiting bodies of the medicinal fungus Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes isolated from A. camphorata, and compounds 3 and 4 are the first pair of cis-trans isomers of ergostane-type triterpenoids containing an aldehyde group. Compounds 5-12 are four pairs of C-25 epimers. The structures of 1-12 were elucidated on the basis of extensive spectroscopic data analysis including NMR and HRESIMS. Particularly, the absolute configurations at C-25 for 5-12 were determined by the modified Mosher's method. These triterpenoids exhibited weak cytotoxic activities against MDA-MB-231 breast cancer cells and A549 lung cancer cells, but did not inhibit the growth of normal cells in the sulforhodamine B assay.
AB - Twelve ergostanoids, named antcamphins A-L (1-12), together with 20 known triterpenoids, were isolated from fruiting bodies of the medicinal fungus Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes isolated from A. camphorata, and compounds 3 and 4 are the first pair of cis-trans isomers of ergostane-type triterpenoids containing an aldehyde group. Compounds 5-12 are four pairs of C-25 epimers. The structures of 1-12 were elucidated on the basis of extensive spectroscopic data analysis including NMR and HRESIMS. Particularly, the absolute configurations at C-25 for 5-12 were determined by the modified Mosher's method. These triterpenoids exhibited weak cytotoxic activities against MDA-MB-231 breast cancer cells and A549 lung cancer cells, but did not inhibit the growth of normal cells in the sulforhodamine B assay.
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U2 - 10.1021/np400741s
DO - 10.1021/np400741s
M3 - Article
VL - 77
SP - 118
EP - 124
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 1
ER -