Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy

H. S. Liu, H. W. Chung, C. J. Juan, S. Y. Tsai, C. Y. Wang, C. C. Chan, G. S. Huang, M. C. Chou, C. S. Lee, C. W. Ko, N. Y. Cho, Cheng Yu Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The signal-intensity loss from anomalous J-modulation effects due to chemical-shift displacement was investigated on amino acid groups (alanine, valine, leucine, and isoleucine) at 3T by using point-resolved 1H spectroscopy in patients with brain abscess and phantom experiments. With a larger chemical shift between methyl and methine resonances, alanine shows a greater effect of signal-intensity cancellation compared with other amino acids around 0.9 ppm, resulting in noninverted doublets at a TE of 144 ms.

Original languageEnglish
Pages (from-to)1644-1648
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume29
Issue number9
DOIs
Publication statusPublished - Oct 2008
Externally publishedYes

Fingerprint

Alanine
Magnetic Resonance Spectroscopy
Amino Acids
Brain Abscess
Isoleucine
Valine
Leucine
Spectrum Analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

Cite this

Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy. / Liu, H. S.; Chung, H. W.; Juan, C. J.; Tsai, S. Y.; Wang, C. Y.; Chan, C. C.; Huang, G. S.; Chou, M. C.; Lee, C. S.; Ko, C. W.; Cho, N. Y.; Chen, Cheng Yu.

In: American Journal of Neuroradiology, Vol. 29, No. 9, 10.2008, p. 1644-1648.

Research output: Contribution to journalArticle

Liu, HS, Chung, HW, Juan, CJ, Tsai, SY, Wang, CY, Chan, CC, Huang, GS, Chou, MC, Lee, CS, Ko, CW, Cho, NY & Chen, CY 2008, 'Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy', American Journal of Neuroradiology, vol. 29, no. 9, pp. 1644-1648. https://doi.org/10.3174/ajnr.A1131
Liu, H. S. ; Chung, H. W. ; Juan, C. J. ; Tsai, S. Y. ; Wang, C. Y. ; Chan, C. C. ; Huang, G. S. ; Chou, M. C. ; Lee, C. S. ; Ko, C. W. ; Cho, N. Y. ; Chen, Cheng Yu. / Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy. In: American Journal of Neuroradiology. 2008 ; Vol. 29, No. 9. pp. 1644-1648.
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