Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy

H. S. Liu, H. W. Chung, C. J. Juan, S. Y. Tsai, C. Y. Wang, C. C. Chan, G. S. Huang, M. C. Chou, C. S. Lee, C. W. Ko, N. Y. Cho, Cheng Yu Chen

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3 Citations (Scopus)


The signal-intensity loss from anomalous J-modulation effects due to chemical-shift displacement was investigated on amino acid groups (alanine, valine, leucine, and isoleucine) at 3T by using point-resolved 1H spectroscopy in patients with brain abscess and phantom experiments. With a larger chemical shift between methyl and methine resonances, alanine shows a greater effect of signal-intensity cancellation compared with other amino acids around 0.9 ppm, resulting in noninverted doublets at a TE of 144 ms.

Original languageEnglish
Pages (from-to)1644-1648
Number of pages5
JournalAmerican Journal of Neuroradiology
Issue number9
Publication statusPublished - Oct 2008
Externally publishedYes


ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

Cite this

Liu, H. S., Chung, H. W., Juan, C. J., Tsai, S. Y., Wang, C. Y., Chan, C. C., Huang, G. S., Chou, M. C., Lee, C. S., Ko, C. W., Cho, N. Y., & Chen, C. Y. (2008). Anomalous J-modulation effects on amino acids in clinical 3T MR spectroscopy. American Journal of Neuroradiology, 29(9), 1644-1648.