Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis

Shin Chen Hou, Li Wei Chan, Yu Chi Chou, Ching Yuan Su, Xin Chen, Yen Ling Shih, Pei Chun Tsai, C. K.James Shen, Yu Ting Yan

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Ankyrin repeat domain 17 (Ankrd17) encodes an ubiquitously expressed protein with two clusters of ankyrin repeats. We have used gene targeting strategy to ablate the Ankrd17 gene in mouse. The Ankrd17-deficient mice died between embryonic day (E) 10.5 and E11.5 due to cardiovascular defects. Serious hemorrhages were detected and the vascular smooth muscle cells (vSMCs) surrounding the vessels were drastically reduced in the Ankrd17-deficient embryos, suggesting that the vascular maturation was not completed. Interestingly, vSMC differentiation marker genes were up-regulated in the mutant embryos. Our data have demonstrated the indispensability of Ankrd17 functioning for vascular maturation during early development. The Ankrd17-deficient mice also provide a new animal model for the analysis of the regulatory pathways of the differentiation of vSMC precursor cells.

Original languageEnglish
Pages (from-to)2765-2771
Number of pages7
JournalFEBS Letters
Volume583
Issue number17
DOIs
Publication statusPublished - Sep 3 2009
Externally publishedYes

Keywords

  • Ankyrin factor
  • Mouse gene targeting
  • SM α-actin gene
  • Smooth muscle cell
  • Vascular integrity

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Hou, S. C., Chan, L. W., Chou, Y. C., Su, C. Y., Chen, X., Shih, Y. L., Tsai, P. C., Shen, C. K. J., & Yan, Y. T. (2009). Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis. FEBS Letters, 583(17), 2765-2771. https://doi.org/10.1016/j.febslet.2009.07.025