Animal models and in vivo investigations for drug repurposing in lung cancer

Hsuen Wen Kate Chang, Vincent H.S. Chang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Lung cancer is the leading cause of cancer deaths worldwide. The difficulties of early detection and treatment resistance adversely affect prognosis. Major challenges for new drug development include cost, safety, and efficacy. As a result, repurposing existing drugs for new indications offers a more favorable risk-return trade-off than other available drug development strategies. Numerous mouse models for lung cancer have been established, which can primarily be divided into genetically engineered or xenograft mouse models. However, genetically modulated models cannot fully represent the systemic complexity of lung cancer, and xenograft models do not behave identically to human lung tumors in drug repurposing. This chapter reviews the current animal models in lung cancer drug repurposing and assesses the challenges and future directions of this field.

Original languageEnglish
Title of host publicationDrug Repurposing in Cancer Therapy
Subtitle of host publicationApproaches and Applications
PublisherElsevier
Pages273-293
Number of pages21
ISBN (Electronic)9780128196687
DOIs
Publication statusPublished - Jan 1 2020

Keywords

  • Drug repurposing
  • Genetically engineered mouse models
  • Lung
  • Non-small cell lung cancer
  • Small cell lung cancer
  • Squamous cell lung cancer
  • Xenograft models

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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