Angiotensin receptor blockade blunts hyperinsulinemia-induced hypertension in rats

Te Chao Fang, Wann Chu Huang

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The study was conducted to examine the effects of the angiotensin subtype 1 and 2 receptor antagonists (losartan and PD123319, respectively) on blood pressure (BP) and renal excretory function in chronic hyperinsulinemia- induced hypertension in rats. Hyperinsulinemia was achieved by insulin infusion (21.5 pmol/kg per minute) via osmotic minipump for 6 weeks. Losartan or PD 123319 was coinfused either at the beginning or after 4 weeks of insulin infusion. The results showed that insulin infusion significantly increased the plasma insulin concentration from 259.0±22.2 to 646.5±33.0 and 713.9±26.5 pmol/L (P

Original languageEnglish
Pages (from-to)235-242
Number of pages8
JournalHypertension
Volume32
Issue number2
Publication statusPublished - Aug 1998
Externally publishedYes

Keywords

  • Angiotensin receptor antagonist
  • Hyperinsulinemia
  • Insulin resistance
  • Losartan
  • PD123319

ASJC Scopus subject areas

  • Internal Medicine

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