Angiotensin-converting enzyme inhibitors and bacterial pneumonia in patients with Parkinson disease

Han Cheng Wang, Che Chen Lin, Chi Ieong Lau, Anna Chang, Chia Hung Kao

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: To evaluate the association of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with pneumonia development in patients with Parkinson's disease (PD). Methods: The study cohort consisted of patients aged 50 years or older who were initially diagnosed with PD and had hypertension. We assessed the patients' exposure statuses and accumulated doses of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers. We then evaluated the risk of pneumonia development in the patients who were exposed to these drugs and those who were not. Results: We examined 2,310 patients. During the observation period, 608 patients developed pneumonia. Angiotensin-converting enzyme inhibitors were associated with a lower risk of pneumonia. This association was dose-dependent. Conclusion: Angiotensin-converting enzyme inhibitor use was associated with a dose-dependent reduction in the risk of pneumonia in patients with PD and hypertension.

Original languageEnglish
Pages (from-to)593-596
Number of pages4
JournalMovement Disorders
Volume30
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

Fingerprint

Bacterial Pneumonia
Angiotensin-Converting Enzyme Inhibitors
Parkinson Disease
Pneumonia
Angiotensin Receptor Antagonists
Hypertension
Risk Reduction Behavior
Cohort Studies
Observation
Pharmaceutical Preparations

Keywords

  • Angiotensin II receptor blockers
  • Angiotensin-converting enzyme inhibitors
  • Hypertension
  • Parkinson's disease
  • Pneumonia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Angiotensin-converting enzyme inhibitors and bacterial pneumonia in patients with Parkinson disease. / Wang, Han Cheng; Lin, Che Chen; Lau, Chi Ieong; Chang, Anna; Kao, Chia Hung.

In: Movement Disorders, Vol. 30, No. 4, 01.04.2015, p. 593-596.

Research output: Contribution to journalArticle

Wang, Han Cheng ; Lin, Che Chen ; Lau, Chi Ieong ; Chang, Anna ; Kao, Chia Hung. / Angiotensin-converting enzyme inhibitors and bacterial pneumonia in patients with Parkinson disease. In: Movement Disorders. 2015 ; Vol. 30, No. 4. pp. 593-596.
@article{af3951e923dc42daa0f7cc919241e3ac,
title = "Angiotensin-converting enzyme inhibitors and bacterial pneumonia in patients with Parkinson disease",
abstract = "Background: To evaluate the association of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with pneumonia development in patients with Parkinson's disease (PD). Methods: The study cohort consisted of patients aged 50 years or older who were initially diagnosed with PD and had hypertension. We assessed the patients' exposure statuses and accumulated doses of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers. We then evaluated the risk of pneumonia development in the patients who were exposed to these drugs and those who were not. Results: We examined 2,310 patients. During the observation period, 608 patients developed pneumonia. Angiotensin-converting enzyme inhibitors were associated with a lower risk of pneumonia. This association was dose-dependent. Conclusion: Angiotensin-converting enzyme inhibitor use was associated with a dose-dependent reduction in the risk of pneumonia in patients with PD and hypertension.",
keywords = "Angiotensin II receptor blockers, Angiotensin-converting enzyme inhibitors, Hypertension, Parkinson's disease, Pneumonia",
author = "Wang, {Han Cheng} and Lin, {Che Chen} and Lau, {Chi Ieong} and Anna Chang and Kao, {Chia Hung}",
year = "2015",
month = "4",
day = "1",
doi = "10.1002/mds.26136",
language = "English",
volume = "30",
pages = "593--596",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Angiotensin-converting enzyme inhibitors and bacterial pneumonia in patients with Parkinson disease

AU - Wang, Han Cheng

AU - Lin, Che Chen

AU - Lau, Chi Ieong

AU - Chang, Anna

AU - Kao, Chia Hung

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Background: To evaluate the association of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with pneumonia development in patients with Parkinson's disease (PD). Methods: The study cohort consisted of patients aged 50 years or older who were initially diagnosed with PD and had hypertension. We assessed the patients' exposure statuses and accumulated doses of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers. We then evaluated the risk of pneumonia development in the patients who were exposed to these drugs and those who were not. Results: We examined 2,310 patients. During the observation period, 608 patients developed pneumonia. Angiotensin-converting enzyme inhibitors were associated with a lower risk of pneumonia. This association was dose-dependent. Conclusion: Angiotensin-converting enzyme inhibitor use was associated with a dose-dependent reduction in the risk of pneumonia in patients with PD and hypertension.

AB - Background: To evaluate the association of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with pneumonia development in patients with Parkinson's disease (PD). Methods: The study cohort consisted of patients aged 50 years or older who were initially diagnosed with PD and had hypertension. We assessed the patients' exposure statuses and accumulated doses of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers. We then evaluated the risk of pneumonia development in the patients who were exposed to these drugs and those who were not. Results: We examined 2,310 patients. During the observation period, 608 patients developed pneumonia. Angiotensin-converting enzyme inhibitors were associated with a lower risk of pneumonia. This association was dose-dependent. Conclusion: Angiotensin-converting enzyme inhibitor use was associated with a dose-dependent reduction in the risk of pneumonia in patients with PD and hypertension.

KW - Angiotensin II receptor blockers

KW - Angiotensin-converting enzyme inhibitors

KW - Hypertension

KW - Parkinson's disease

KW - Pneumonia

UR - http://www.scopus.com/inward/record.url?scp=84926147623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926147623&partnerID=8YFLogxK

U2 - 10.1002/mds.26136

DO - 10.1002/mds.26136

M3 - Article

VL - 30

SP - 593

EP - 596

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 4

ER -