Angiostrongylus cantonensis: Apoptosis of inflammatory cells induced by treatment with mebendazole or/and interleukin 12 in mice

Chih Cheng Chuang, Chi Wu Chen, Chia-Kwung Fan, Kua-Eyre Su, Yueh Ting Tsai, Chih Li Chen, W. Y. Du

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Angiostrongylus cantonensis is the major cause of human eosinophilic meningoencephalitis. ICR mice were infected orally with 35 infective larvae and sacrificed at 4-14 days, 25 days or 32 days post infection (dpi) for pathological and immunocytochemical examinations. In the non-treated group, no apoptosis signal was found in the meninges or parenchyma of the brains (4-14 dpi). Only a few apoptotic cells were noticed at 25 dpi (3%) and 32 dpi (10%). In the groups, the animals were given a single dose of mebendazole (20 mg/kg, per os at various times) or injections of interleukin 12 (IL-12) (10 ng/daily, intraperitoneally), all the animals were sacrificed at 14 dpi; the number of apoptotic cells was increased (17-21%). In the group that received a single dose of mebendazole (4 dpi) in combination with IL-12 injections (4-13 dpi), mild meningitis was observed, and most of the infiltrated inflammatory cells were in the apoptotic program (55%). Taken together, apoptosis of the inflammatory cells (most were eosinophils) could be induced when the infected mice were treated with mebendazole or/and IL-12.

Original languageEnglish
Pages (from-to)226-232
Number of pages7
JournalExperimental Parasitology
Volume115
Issue number3
DOIs
Publication statusPublished - Mar 2007

Fingerprint

Angiostrongylus cantonensis
Mebendazole
Interleukin-12
Infection
Therapeutics
Meninges
Inbred ICR Mouse
Injections
Meningoencephalitis
Pyroptosis
Meningitis
Eosinophils
Interleukin-10
Larva
Cell Count
Apoptosis
Brain

Keywords

  • Angiostrongylus cantonensis
  • Apoptosis

ASJC Scopus subject areas

  • Immunology
  • Parasitology
  • Infectious Diseases

Cite this

Angiostrongylus cantonensis : Apoptosis of inflammatory cells induced by treatment with mebendazole or/and interleukin 12 in mice. / Chuang, Chih Cheng; Chen, Chi Wu; Fan, Chia-Kwung; Su, Kua-Eyre; Tsai, Yueh Ting; Chen, Chih Li; Du, W. Y.

In: Experimental Parasitology, Vol. 115, No. 3, 03.2007, p. 226-232.

Research output: Contribution to journalArticle

Chuang, Chih Cheng ; Chen, Chi Wu ; Fan, Chia-Kwung ; Su, Kua-Eyre ; Tsai, Yueh Ting ; Chen, Chih Li ; Du, W. Y. / Angiostrongylus cantonensis : Apoptosis of inflammatory cells induced by treatment with mebendazole or/and interleukin 12 in mice. In: Experimental Parasitology. 2007 ; Vol. 115, No. 3. pp. 226-232.
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