Angiostrongylus cantonensis: Apoptosis of inflammatory cells induced by treatment with mebendazole or/and interleukin 12 in mice

Chih Cheng Chuang, Chi Wu Chen, Chia-Kwung Fan, Kua-Eyre Su, Yueh Ting Tsai, Chih Li Chen, W. Y. Du

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Angiostrongylus cantonensis is the major cause of human eosinophilic meningoencephalitis. ICR mice were infected orally with 35 infective larvae and sacrificed at 4-14 days, 25 days or 32 days post infection (dpi) for pathological and immunocytochemical examinations. In the non-treated group, no apoptosis signal was found in the meninges or parenchyma of the brains (4-14 dpi). Only a few apoptotic cells were noticed at 25 dpi (3%) and 32 dpi (10%). In the groups, the animals were given a single dose of mebendazole (20 mg/kg, per os at various times) or injections of interleukin 12 (IL-12) (10 ng/daily, intraperitoneally), all the animals were sacrificed at 14 dpi; the number of apoptotic cells was increased (17-21%). In the group that received a single dose of mebendazole (4 dpi) in combination with IL-12 injections (4-13 dpi), mild meningitis was observed, and most of the infiltrated inflammatory cells were in the apoptotic program (55%). Taken together, apoptosis of the inflammatory cells (most were eosinophils) could be induced when the infected mice were treated with mebendazole or/and IL-12.

Original languageEnglish
Pages (from-to)226-232
Number of pages7
JournalExperimental Parasitology
Volume115
Issue number3
DOIs
Publication statusPublished - Mar 2007

Keywords

  • Angiostrongylus cantonensis
  • Apoptosis

ASJC Scopus subject areas

  • Immunology
  • Parasitology
  • Infectious Diseases

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