Angiopoietin-like protein 1 expression is related to intermuscular connective tissue and cartilage development

Dar Ming Lai, Yong Kwang Tu, Yu Hsuan Hsieh, Wen Ming Hsu, Chin Cheng Lee, Wei Cheng Cheng, Fon Jou Hsieh, Hung Li

Research output: Contribution to journalArticle

7 Citations (Scopus)


Angptl1, a member of the angiopoietin-related protein family, is known to regulate angiogenesis, but little is known of its potential role in other processes. To identify the expression pattern and possible role of angptl1 during embryogenesis, we used gene targeting to generate angptl1-deficient, nLacZ knockin mice. Staining for β-galactosidase from embryonic day 9.5 to 6 months of age revealed that angptl1 was initially expressed in the paraxial mesoderm. Expression then shifted to intermuscular connective tissue (fascial plane), joint capsules, and perichondrium (laryngo-trachea, ribs, and long bones), but not the muscles. The vasculature, central and peripheral nervous systems, digestive, respiratory, and other major organ systems did not show any angptl1 expression. This expression pattern suggests that angptl1 is related to development of the connective tissue and cartilage. Lack of phenotype in mutant mice may be due to a functional redundancy from other related factors.

Original languageEnglish
Pages (from-to)2643-2652
Number of pages10
JournalDevelopmental Dynamics
Issue number9
Publication statusPublished - Sep 1 2007
Externally publishedYes


  • Angiopoietin
  • Cartilage
  • Connective tissue
  • Mesenchyme
  • Vascular

ASJC Scopus subject areas

  • Developmental Biology

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