Angiopoietin-2 Is Associated with Albuminuria and Microinflammation in Chronic Kidney Disease

Fan Chi Chang, Tai Shuan Lai, Chih Kang Chiang, Yung Ming Chen, Ming Shiou Wu, Tzong Shinn Chu, Kwan Dun Wu, Shuei Liong Lin

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Abstract

Although cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD), the pathophysiology is not thoroughly understood. Given that elevated albuminuria or circulating angiopoietin-2 associates with CVD and mortality in CKD patients, we were intrigued by the relationship between albuminuria and angiopoietin-2. A total of 416 patients with CKD stages 3 to 5 were stratified by urine albumin-creatinine ratio as normoalbuminuria (300 mg/g). The levels of plasma angiopoietin-2 and vascular endothelial growth factor (VEGF) increased, and soluble Tie-2 decreased in the subgroups of albuminuria; whereas angiopoietin-1 did not change. Linear regression showed a positive correlation between urine albumin-creatinine ratio (ACR) and plasma angiopoietin-2 (correlation coefficient r = 0.301, 95% confidence interval 0.211-0.386, P

Original languageEnglish
Article numbere54668
JournalPLoS One
Volume8
Issue number3
DOIs
Publication statusPublished - Mar 1 2013
Externally publishedYes

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Chang, F. C., Lai, T. S., Chiang, C. K., Chen, Y. M., Wu, M. S., Chu, T. S., Wu, K. D., & Lin, S. L. (2013). Angiopoietin-2 Is Associated with Albuminuria and Microinflammation in Chronic Kidney Disease. PLoS One, 8(3), [e54668]. https://doi.org/10.1371/journal.pone.0054668