Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients

Chun Pin Chiang, Julia Yu Fong Chang, Yi Ping Wang, Yu Hsueh Wu, Yang Che Wu, Andy Sun

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background/Purpose: Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA + AG) and GPCA-negative AG (GPCA AG) patients. Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA + AG, 780 GPCA AG patients, and 532 healthy control subjects. Results: Both 284 GPCA + AG and 780 GPCA AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA + AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA AG patients. Sixty-three (22.2%) of 284 GPCA + AG patients and 139 (17.8%) of 780 GPCA AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA + AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA AG patients. Conclusion: The disease of AG itself is a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in both GPCA + AG and GPCA AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA + AG patients.

Original languageEnglish
Pages (from-to)565-571
Number of pages7
JournalJournal of the Formosan Medical Association
Volume118
Issue number2
DOIs
Publication statusPublished - Feb 1 2019
Externally publishedYes

Fingerprint

Glossitis
Gastric Parietal Cells
Hematinics
Hyperhomocysteinemia
Anemia
Antibodies
Vitamin B 12 Deficiency
Iron-Deficiency Anemias
Vitamin B 12
Healthy Volunteers
Hemoglobins
Iron
Serum

Keywords

  • Anemia
  • Atrophic glossitis
  • Gastric parietal cell antibody
  • Hyperhomocysteinemia
  • Vitamin B12 deficiency

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients. / Chiang, Chun Pin; Chang, Julia Yu Fong; Wang, Yi Ping; Wu, Yu Hsueh; Wu, Yang Che; Sun, Andy.

In: Journal of the Formosan Medical Association, Vol. 118, No. 2, 01.02.2019, p. 565-571.

Research output: Contribution to journalArticle

@article{cdd877cae3d4430ea053d118fd941623,
title = "Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients",
abstract = "Background/Purpose: Approximately 27{\%} of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA + AG) and GPCA-negative AG (GPCA − AG) patients. Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA + AG, 780 GPCA − AG patients, and 532 healthy control subjects. Results: Both 284 GPCA + AG and 780 GPCA − AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA + AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA − AG patients. Sixty-three (22.2{\%}) of 284 GPCA + AG patients and 139 (17.8{\%}) of 780 GPCA − AG patients had anemia. The normocytic anemia (42.9{\%}), pernicious anemia (34.9{\%}), and iron deficiency anemia (15.9{\%}) were the three most common types of anemia in the 63 anemic GPCA + AG patients. Moreover, the normocytic anemia (64.8{\%}), iron deficiency anemia (14.4{\%}), and thalassemia trait-induced anemia (13.7{\%}) were the three most common types of anemia in 139 anemic GPCA − AG patients. Conclusion: The disease of AG itself is a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in both GPCA + AG and GPCA − AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA + AG patients.",
keywords = "Anemia, Atrophic glossitis, Gastric parietal cell antibody, Hyperhomocysteinemia, Vitamin B12 deficiency",
author = "Chiang, {Chun Pin} and Chang, {Julia Yu Fong} and Wang, {Yi Ping} and Wu, {Yu Hsueh} and Wu, {Yang Che} and Andy Sun",
year = "2019",
month = "2",
day = "1",
doi = "10.1016/j.jfma.2018.12.005",
language = "English",
volume = "118",
pages = "565--571",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",
number = "2",

}

TY - JOUR

T1 - Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients

AU - Chiang, Chun Pin

AU - Chang, Julia Yu Fong

AU - Wang, Yi Ping

AU - Wu, Yu Hsueh

AU - Wu, Yang Che

AU - Sun, Andy

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Background/Purpose: Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA + AG) and GPCA-negative AG (GPCA − AG) patients. Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA + AG, 780 GPCA − AG patients, and 532 healthy control subjects. Results: Both 284 GPCA + AG and 780 GPCA − AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA + AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA − AG patients. Sixty-three (22.2%) of 284 GPCA + AG patients and 139 (17.8%) of 780 GPCA − AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA + AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA − AG patients. Conclusion: The disease of AG itself is a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in both GPCA + AG and GPCA − AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA + AG patients.

AB - Background/Purpose: Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA + AG) and GPCA-negative AG (GPCA − AG) patients. Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA + AG, 780 GPCA − AG patients, and 532 healthy control subjects. Results: Both 284 GPCA + AG and 780 GPCA − AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA + AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA − AG patients. Sixty-three (22.2%) of 284 GPCA + AG patients and 139 (17.8%) of 780 GPCA − AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA + AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA − AG patients. Conclusion: The disease of AG itself is a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in both GPCA + AG and GPCA − AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA + AG patients.

KW - Anemia

KW - Atrophic glossitis

KW - Gastric parietal cell antibody

KW - Hyperhomocysteinemia

KW - Vitamin B12 deficiency

UR - http://www.scopus.com/inward/record.url?scp=85058633737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058633737&partnerID=8YFLogxK

U2 - 10.1016/j.jfma.2018.12.005

DO - 10.1016/j.jfma.2018.12.005

M3 - Article

C2 - 30581105

AN - SCOPUS:85058633737

VL - 118

SP - 565

EP - 571

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

IS - 2

ER -