Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients

Chun Pin Chiang, Julia Yu Fong Chang, Yi Ping Wang, Yu Hsueh Wu, Yang Che Wu, Andy Sun

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background/Purpose: Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCA + AG) and GPCA-negative AG (GPCA AG) patients. Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCA + AG, 780 GPCA AG patients, and 532 healthy control subjects. Results: Both 284 GPCA + AG and 780 GPCA AG patients had significantly higher frequencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 532 healthy control subjects. Moreover, 284 GPCA + AG patients had significantly higher frequencies of macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia than 780 GPCA AG patients. Sixty-three (22.2%) of 284 GPCA + AG patients and 139 (17.8%) of 780 GPCA AG patients had anemia. The normocytic anemia (42.9%), pernicious anemia (34.9%), and iron deficiency anemia (15.9%) were the three most common types of anemia in the 63 anemic GPCA + AG patients. Moreover, the normocytic anemia (64.8%), iron deficiency anemia (14.4%), and thalassemia trait-induced anemia (13.7%) were the three most common types of anemia in 139 anemic GPCA AG patients. Conclusion: The disease of AG itself is a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in both GPCA + AG and GPCA AG patients. The serum GPCA also plays a significant role in causing macrocytosis, vitamin B12 deficiency, and hyperhomocysteinemia in GPCA + AG patients.

Original languageEnglish
Pages (from-to)565-571
Number of pages7
JournalJournal of the Formosan Medical Association
Volume118
Issue number2
DOIs
Publication statusPublished - Feb 1 2019
Externally publishedYes

Keywords

  • Anemia
  • Atrophic glossitis
  • Gastric parietal cell antibody
  • Hyperhomocysteinemia
  • Vitamin B12 deficiency

ASJC Scopus subject areas

  • Medicine(all)

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