Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive and -negative recurrent aphthous stomatitis patients with anti-thyroid antibody positivity

Yu Hsueh Wu, Julia Yu-Fong Chang, Yi Ping Wang, Yang Che Wu, Hsin Ming Chen, Andy Sun

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33 Citations (Scopus)

Abstract

Background/purpose Serum anti-gastric parietal cell (GPCA), anti-thyroglobulin (TGA), and anti-thyroid microsomal antibodies (TMA) can be found in some recurrent aphthous stomatitis (RAS) patients. This study mainly assessed whether serum GPCA, TGA, TMA and RAS itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive RAS patients with GPCA positivity (GPCA+/TGA/TMA/RAS patients) or negativity (GPCA−/TGA/TMA/RAS patients). Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 15 GPCA+/TGA/TMA/RAS patients, 69 GPCA−/TGA/TMA/RAS patients, 240 all autoantibodies-negative RAS patients (Abs−/RAS patients), and 342 healthy control subjects. Results GPCA+/TGA/TMA/RAS patients had significantly lower mean Hb (for men only) and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. GPCA+/TGA/TMA/RAS patients had lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA−/TGA/TMA/RAS patients. Furthermore, both GPCA−/TGA/TMA/RAS and Abs−/RAS patients did have significantly lower mean Hb, MCV, and iron levels as well as significantly greater frequencies of Hb, iron and vitamin B12 deficiencies than healthy control subjects. There were no significant differences in blood data between GPCA−/TGA/TMA/RAS and Abs−/RAS patients Conclusion Both serum GPCA positivity and RAS itself are the contributing factors causing anemia and hematinic deficiencies in GPCA+/TGA/TMA/RAS patients. RAS itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA−/TGA/TMA/RAS patients.

Original languageEnglish
Pages (from-to)145-152
Number of pages8
JournalJournal of the Formosan Medical Association
Volume116
Issue number3
DOIs
Publication statusPublished - Mar 1 2017
Externally publishedYes

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Keywords

  • Anti-gastric parietal cell antibody
  • Anti-thyroid antibody
  • Macrocytosis
  • Pernicious anemia
  • Recurrent aphthous stomatitis
  • Vitamin B12 deficiency

ASJC Scopus subject areas

  • Medicine(all)

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